Descripción
IL-1α and IL-1β are potent pro-inflammatory cytokines that induce a wide range of biological activities in various cell types. Two distinct types of IL-1 receptors have been identified and cloned from human and mouse cells. IL-1 Receptor Type I is an 80 kDa transmembrane protein with a well-established role in IL-1 signal transduction. IL-1 Receptor Type II is a 68 kDa membrane protein with a relatively short cytoplasmic tail that lacks signaling capability. The Type II receptor acts as a decoy target for IL-1, inhibiting IL-1 activity by preventing its binding to the Type I receptor. A soluble form of the Type II receptor is induced by anti-inflammatory agents such as glucocorticoids, IL-4, and IL-13.
This product is provided as a liquid and features high purity, high bioactivity, and low endotoxin levels.
Components
|
Name |
90278ES05 |
90278ES10 |
90278ES50 |
90278ES60 |
90278ES80 |
|
Recombinant Human IL-1α Protein (HEK293) |
2 μg |
10 μg |
50 μg(5 ×10 μg) |
100 μg |
1 mg |
Specifications
|
Synonyms |
IL-3, h-IL-3, rh-IL-3, IL-3, interleukin-3, TCGF |
|
Species |
Human |
|
Source |
HEK293 cells |
|
Sequence |
Ser113–Ala271 |
|
Accession |
P01583 |
|
Tag |
No Tag |
|
Molecular Weight |
The protein has a predicted molecular weight of 18.0 kDa |
|
Endotoxin |
< 0.01 EU per μg, as determined by the LAL method |
|
Purity |
> 95%, determined by SDS-PAGE |
|
Activity |
Measured by cell proliferation assay using D10.G4.1 mouse helper T cells. The EC₅₀ for this effect is 1–6 pg/mL |
|
Formulation |
Dissolved in sterile PBS buffer |
|
Appearance |
Liquid |
Storage
Store at –85°C ~ –65°C. The product is stable for one year upon receipt.
Avoid repeated freeze-thaw cycles. Centrifuge the vial before opening. It is recommended to aliquot the product into single-use volumes and store the aliquots at –80°C.
Documents:
Safety Data Sheet
90278_MSDS_HB251015_EN.PDF
Manuals
Pago y seguridad
Su información de pago se procesa de forma segura. No almacenamos detalles de la tarjeta de crédito ni tenemos acceso a la información de su tarjeta de crédito.
Consulta
También te puede gustar
Preguntas frecuentes
El producto es solo para fines de investigación y no está destinado a uso terapéutico o diagnóstico en humanos o animales. Los productos y el contenido están protegidos por patentes, marcas comerciales y derechos de autor propiedad de Yeasen Biotechnology. Los símbolos de marca comercial indican el país de origen, no necesariamente el registro en todas las regiones.
Algunas aplicaciones pueden requerir derechos de propiedad intelectual adicionales de terceros.
Yeasen se dedica a la ciencia ética y cree que nuestra investigación debe abordar cuestiones críticas al tiempo que garantiza la seguridad y los estándares éticos.