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Hepatocyte Growth Factor(HGF), also known as Scatter Factor and Hepatopoietin A, is a pleiotropic protein in the Plasminogen subfamily of S1 peptidases. It is a multidomain molecule that includes an N-terminal PAN/APPLE-like domain, four Kringle domains, and a serine proteinase-like domain that has no detectable protease activity (1 - 5). Mouse HGF is secreted as an inactive 728 amino acid (aa) single chain propeptide. It is cleaved after the fourth Kringle domain by a serine protease to form bioactive disulfide-linked HGF with a 60 kDa alpha and 30 kDa beta chain.
Specification
|
Synonyms |
F-TCF; hepatocyte growth factor (hepapoietin A; scatter factor); Hepatopoeitin-A; Hepatopoietin A; |
|
Uniprot No. |
P08048 |
|
Source |
Human HGF Protein is expressed from HEK293 without tag. It contains Gln33-Arg495 (alpha)&Vla496-Leu728(beta). |
|
Molecular Weight |
The protein has a predicted 79.3 kDa |
|
Purity |
> 95% as determined by SDS-PAGE. |
|
Biological Activity |
Measured in a cell proliferation assay using mIMCD-3 mouse epithelial cells. The EC50 for this effect is 1-10 ng/mL. |
|
Endotoxin |
< 0.01 EU per 1 μg of the protein by the LAL method. |
|
Formulation |
Dissolved in sterile PBS buffer. |
|
Concentration |
0.2 mg/ml |
Storage
The product should be stored at -85~-65℃ for 1 year from date of receipt.
Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
Caution
1.Please operate with lab coats and disposable gloves,for your safety.
2.This product is for research use only.
Storage
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