Tanım
Interleukin-6 (IL-6) is a pleiotropic cytokine with diverse biological functions, playing a crucial role in both the immune system and other physiological processes. It is involved in host defense against infections and tissue injuries, acting as a mediator of the acute-phase response, stimulating B and T cell activation and differentiation, and inducing the production of acute-phase proteins like C-reactive protein (CRP). IL-6 also has roles in hematopoiesis, muscle metabolism, and even impacts the brain.
This product is expressed in Escherichia coli and provided in liquid form, with the characteristics of high activity, high purity, and low endotoxin.
Application
Promotes the proliferation of hematopoietic stem cells (HSCs).
Induces the maturation of immature dendritic cells (iDCs) into mature dendritic cells (mDCs).
Participates in the expansion and modulation of other immune cells, such as B cells, T cells, and NK cells.
Components
|
Name |
90211ES10 |
90211ES50 |
90211ES60 |
90211ES80 |
|
Recombinant Human IL-6 GMP
Protein
|
10 μg |
50 μg |
100 μg |
1 mg |
Performance parameters
|
Synonyms |
Interleukin-6, BSF2, HSF, IFNB2, IL6 |
|
Source |
Human IL-6 Protein is expressed from E.coli without tag. It contains Val30-Met212. |
|
Molecular Weight |
Approximately 20.8 kDa. |
|
Accession |
P05231 |
|
Biological Activity |
The ED50 as determined by a cell proliferation assay using human TF-1 cells is 0.1-0.8 ng/mL. |
|
Purity |
＞95% as determined by SDS-PAGE. |
|
Appearance |
Liquid |
|
Endotoxin |
＜0.01 EU/μg protein as determined by LAL method. |
|
Sterility |
Negative. |
|
Mycoplasma |
Negative. |
|
Vitro Virus |
Negative. |
|
Host Cell Protein |
Less than 0.5 ng/μg when tested by ELISA. |
|
Host Cell DNA |
Less than 20 ng/mg when tested by qPCR. |
|
Formulation |
0.22 μm filtered concentrated solution in PBS, pH 7.4. |
Storage
This product should be stored at -85~-65℃ for 2 years.
Figure
1. SDS- PAGE
Figure 1. Human IL-6 on SDS-PAGE under reduced condition. The purity is greater than 95%.
2.Cell Based Assay
Figure 2. The ED50 as determined by a cell proliferation assay using human TF-1 cells is 0.1-0.8 ng/mL.
Documents:
Safety Data Sheet
Manuals
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Sorgu
SSS
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