Descrizione
Interferon-gamma (IFN-γ) is an immunomodulatory protein and a member of the interferon family. Primarily produced by activated T cells, NK cells, and certain lymphocyte subsets, IFN-γ is a cytokine with diverse biological functions. It plays a critical regulatory role in immune responses by enhancing the cytotoxic capacity of macrophages and dendritic cells, promoting their release of pro-inflammatory cytokines, and regulating the expression of antigen-presenting molecules, thereby strengthening cellular immune responses. Furthermore, IFN-γ regulates T cell differentiation and function, promotes Th1 cell development, enhances B cell class switching to IgG, and maintains the balance between cellular and humoral immunity.
Features
High Purity: >95% purity to avoid immune responses caused by residual Host Cell Proteins (HCP) or DNA.
Ultra-Low Endotoxin: <10 EU/mg to minimize the risk of fever or inflammation.
Batch-to-Batch Consistency: Ensures stability and reproducibility in cell culture applications.
Regulatory Compliance: Meets regulatory requirements for cell therapy products and supports Investigational New Drug (IND) applications.
Animal-Origin Free (AOF): Free from animal viruses, pathogens, and exogenous factor contamination, ensuring maximum safety.
Components
|
Components No. |
Name |
91224ES20 |
91224ES50 |
91224ES80 |
|
91224 |
Recombinant Human IFN-gamma GMP Protein |
20 μg |
50 μg |
1 mg |
Specifications
|
Synonyms |
Interferon-gamma,IFN-γ,IFG,IFI,IFNG,IFNgamma,IFN-gamma. |
|
Source |
E.coli. |
|
Sequence |
It contains Gln24-Gln166 |
|
Accession |
P01579 |
|
Tag |
No Tag |
|
Molecular Weight |
Approximately 16.9 kDa. |
|
Biological Activity |
Human IFN-gamma GMP Protein inhibits the proliferation of HT-29 cells.the specific activity of GMP Human IFN-gamma Protein is > 0.6×10^6 IU/mg, which is calibrated against human interferon gamma Standard (NIBSC code: 87/586). |
|
Purity |
＞95% as determined by SDS-PAGE and HPLC. |
|
Endotoxin |
＜0.01 EU/μg protein as determined by LAL method. |
|
Sterility |
Negative. |
|
Mycoplasma |
Negative. |
|
Vitro Virus |
Negative. |
|
Host Cell Protein |
Less than 0.5 ng/μg when tested by ELISA. |
|
Host Cell DNA |
Less than 20 ng/mg when tested by qPCR. |
|
Formulation |
0.22 μm filtered concentrated solution in PBS. |
|
Physical Appearance |
Lyophilized Powder |
Storage
This product should be stored at -25~-15℃ for 3 years. After reconstitution, store at -85 to -65°C. Valid for 3 months.
Figure
SDS-PAGE
Figure 1. Human IFN-gamma GMP Protein on SDS-PAGE under reduced condition. The purity is greater than 95
SEC-HPLC
Figure 2. The purity of Human IFN-gamma GMP Protein is greater than 95% as determined by SEC-HPLC.
Cell Based Assay
Figure 3. Human IFN-gamma GMP Protein inhibits the proliferation of HT-29 cells.the specific activity of GMP Human IFN-gamma Protein is > 0.6×10^6 IU/mg, which is calibrated against human interferon gamma Standard (NIBSC code: 87/586)
Documents:
Safety Data Sheet
Manuals
Pagamento e sicurezza
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Indagine
FAQ
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