Publications

1. Hieff UNICON™ Universal SYBR Green qPCR Master mix

🧬 Cell

[1] Li Y, Wang D, Ping X, et al. Local hyperthermia therapy induces browning of white fat and treats obesity. Cell. 2022;185(6):949-966.e19. doi:10.1016/j.cell.2022.02.004 (IF:41.584)

[2] Medina-Puche L, Tan H, Dogra V, et al. A Defense Pathway Linking Plasma Membrane and Chloroplasts and Co-opted by Pathogens. Cell. 2020;182(5):1109-1124.e25. doi:10.1016/j.cell.2020.07.020 (IF:38.637)

[3] Han X, Wang R, Zhou Y, et al. Mapping the Mouse Cell Atlas by Microwell-Seq [published correction appears in Cell. 2018 May 17;173(5):1307]. Cell. 2018;172(5):1091-1107.e17. doi:10.1016/j.cell.2018.02.001 (IF:31.398)

🧫 Immunity

[4] Wan S, Ni L, Zhao X, et al. Costimulation molecules differentially regulate the ERK-Zfp831 axis to shape T follicular helper cell differentiation. Immunity. 2021;54(12):2740-2755.e6. doi:10.1016/j.immuni.2021.09.018 (IF:31.745)

[5] Wang X, Ni L, Wan S, et al. Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells. Immunity. 2020;52(2):328-341.e5. doi:10.1016/j.immuni.2020.01.006 (IF:22.553)

[6] Chang D, Xing Q, Su Y, et al. The Conserved Non-coding Sequences CNS6 and CNS9 Control Cytokine-Induced Rorc Transcription during T Helper 17 Cell Differentiation. Immunity. 2020;53(3):614-626.e4. doi:10.1016/j.immuni.2020.07.012 (IF:22.553)

[7] Lou F, Sun Y, Xu Z, et al. Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis. Immunity. 2020;53(1):204-216.e10. doi:10.1016/j.immuni.2020.06.004 (IF:22.553)

[8] Xiao J, Li W, Zheng X, et al. Targeting 7-Dehydrocholesterol Reductase Integrates Cholesterol Metabolism and IRF3 Activation to Eliminate Infection. Immunity. 2020;52(1):109-122.e6. doi:10.1016/j.immuni.2019.11.015 (IF:21.522)

🧠 Cancer / Disease 

[9] Tang Y, Fang G, Guo F, et al. Selective Inhibition of STRN3-Containing PP2A Phosphatase Restores Hippo Tumor-Suppressor Activity in Gastric Cancer. Cancer Cell. 2020;38(1):115-128.e9. doi:10.1016/j.ccell.2020.05.019 (IF:26.602)

[10] Xia B, Shen X, He Y, et al. SARS-CoV-2 envelope protein causes acute respiratory distress syndrome (ARDS)-like pathological damages and constitutes an antiviral target. Cell Res. 2021;31(8):847-860. doi:10.1038/s41422-021-00519-4 (IF:25.617)

🌿 Nature

[11] Niu B, Liu J, Lv B, et al. Interplay between transforming growth factor-β and Nur77 in dual regulations of inhibitor of differentiation 1 for colonic tumorigenesis. Nat Commun. 2021;12(1):2809. doi:10.1038/s41467-021-23048-5 (IF:14.919)

[12] Yang Z, Xu G, Wang B, et al. USP12 downregulation orchestrates a protumourigenic microenvironment and enhances lung tumour resistance to PD-1 blockade. Nat Commun. 2021;12(1):4852. doi:10.1038/s41467-021-25032-5 (IF:14.919)

🌸 Genome

[13] Wang C, Yang J, Song P, et al. FIONA1 is an RNA N6-methyladenosine methyltransferase affecting Arabidopsis photomorphogenesis and flowering. Genome Biol. 2022;23(1):40. doi:10.1186/s13059-022-02612-2 (IF:13.583)

 

2. Hifair™ 1st Strand cDNA Synthesis SuperMix and Reverse Transcription Kit

🧬 1. Nature / Cell / Science Family

[1] Wang Y, Wang Y, Song D, et al. An RNA-cleaving threose nucleic acid enzyme capable of single point mutation discrimination. Nat Chem. 2022;14(3):350–359. doi:10.1038/s41557-021-00847-3 (IF: 24.427)

[2] Zhang C, Zhou B, Gu F, et al. Micropeptide PACMP inhibition elicits synthetic lethal effects by decreasing CtIP and poly(ADP-ribosyl)ation. Mol Cell. 2022;82(7):1297–1312.e8. doi:10.1016/j.molcel.2022.01.020 (IF: 17.970)

[3] Yu Y, Zhang B, Ji P, et al. Changes to gut amino acid transporters and microbiome associated with increased E/I ratio in Chd8+/- mouse model of ASD-like behavior. Nat Commun. 2022;13(1):1151. doi:10.1038/s41467-022-28746-2 (IF: 14.919)

[4] Wu W, Zhang J, Cao X, Cai Z, Zhao F. Exploring the cellular landscape of circular RNAs using full-length single-cell RNA sequencing. Nat Commun. 2022;13(1):3242. doi:10.1038/s41467-022-30963-8 (IF: 14.919)

[5] Sun X, Peng X, Cao Y, Zhou Y, Sun Y. ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling. Nat Commun. 2020;11(1):2984. doi:10.1038/s41467-020-16799-0 (IF: 11.614)

[6] Mao Z, Xiao H, Shen P, et al. KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discov. 2022;8(1):5. doi:10.1038/s41421-021-00368-w (IF: 10.849)

🌾 2. Plant Science

[1] Qiao J, Jiang H, Lin Y, et al. A novel miR167a-OsARF6-OsAUX3 module regulates grain length and weight in rice. Mol Plant. 2021;14(10):1683–1698. doi:10.1016/j.molp.2021.06.023 (IF: 13.164)

[2] Song JM, Xie WZ, Wang S, et al. Two gap-free reference genomes and a global view of the centromere architecture in rice. Mol Plant. 2021;14(10):1757–1767. doi:10.1016/j.molp.2021.06.018 (IF: 13.164)

[3] Chen Y, Shen J, Zhang L, et al. Nuclear translocation of OsMFT1 that is impeded by OsFTIP1 promotes drought tolerance in rice. Mol Plant. 2021;14(8):1297–1311. doi:10.1016/j.molp.2021.05.001 (IF: 13.164)

[4] Yang L, Chen Y, Xu L, et al. The OsFTIP6-OsHB22-OsMYBR57 module regulates drought response in rice. Mol Plant. 2022;15(7):1227–1242. doi:10.1016/j.molp.2022.06.003 (IF: 13.164)

[5] Zhang L, Zhang F, Zhou X, et al. The tetratricopeptide repeat protein OsTPR075 promotes heading by regulating florigen transport in rice. Plant Cell. 2022;koac190. doi:10.1093/plcell/koac190 (IF: 11.277)

[6] Wang X, Chen K, Zhou M, et al. GmNAC181 promotes symbiotic nodulation and salt tolerance of nodulation by directly regulating GmNINa expression in soybean. New Phytol. 2022;10.1111/nph.18343. doi:10.1111/nph.18343 (IF: 10.152)

[7] Yun J, Sun Z, Jiang Q, et al. The miR156b-GmSPL9d module modulates nodulation by targeting multiple core nodulation genes in soybean. New Phytol. 2022;233(4):1881–1899. doi:10.1111/nph.17899 (IF: 10.152)

[8] Kong D, Pan X, Jing Y, et al. ZmSPL10/14/26 are required for epidermal hair cell fate specification on maize leaf. New Phytol. 2021;230(4):1533–1549. doi:10.1111/nph.17293 (IF: 10.152)

🧫 3. Biomedical and Biomaterials Science

[1] Hu X, Pang J, Zhang J, et al. Discovery of Novel GR Ligands toward Druggable GR Antagonist Conformations Identified by MD Simulations and Markov State Model Analysis. Adv Sci (Weinh). 2022;9(3):e2102435. doi:10.1002/advs.202102435 (IF: 16.806)

[2] Zhong Z, Wu X, Wang Y, et al. Zn/Sr dual ions-collagen co-assembly hydroxyapatite enhances bone regeneration through procedural osteo-immunomodulation and osteogenesis. Bioact Mater. 2021;10:195–206. doi:10.1016/j.bioactmat.2021.09.013 (IF: 14.593)

[3] Liu J, Qu M, Wang C, et al. A Dual-Cross-Linked Hydrogel Patch for Promoting Diabetic Wound Healing. Small. 2022;18(17):e2106172. doi:10.1002/smll.202106172 (IF: 13.281)

[4] Cai Z, Zhang Y, Zhang W, et al. Arsenic retention in erythrocytes and excessive erythrophagocytosis is related to low selenium status by impaired redox homeostasis. Redox Biol. 2022;52:102321. doi:10.1016/j.redox.2022.102321 (IF: 11.799)

[5] Yuan H, Zhao L, Yuan Y, et al. HBx represses WDR77 to enhance HBV replication by DDB1-mediated WDR77 degradation in the liver. Theranostics. 2021;11(17):8362–8378. doi:10.7150/thno.57531 (IF: 11.556)

[6] Ma D, Zhao Y, Huang L, et al. A novel hydrogel-based treatment for complete transection spinal cord injury repair is driven by microglia/macrophages repopulation. Biomaterials. 2020;237:119830. doi:10.1016/j.biomaterials.2020.119830 (IF: 10.317)

 

3. Hieff Trans™ Liposomal Transfection Reagent

🧬 1. Nature / Science / Cell Family 

[1] Liu R, Yang J, Yao J, et al. Optogenetic control of RNA function and metabolism using engineered light-switchable RNA-binding proteins. Nat Biotechnol. 2022;40(5):779–786. doi:10.1038/s41587-021-01112-1 (IF: 54.908)

[2] Tao R, Zhao Y, Chu H, et al. Genetically encoded fluorescent sensors reveal dynamic regulation of NADPH metabolism. Nat Methods. 2017;14(7):720–728. doi:10.1038/nmeth.4306 (IF: 25.062)

[3] Huang K, Chen X, Li C, et al. Structure-based investigation of fluorogenic Pepper aptamer. Nat Chem Biol. 2021;17(12):1289–1295. doi:10.1038/s41589-021-00884-6 (IF: 15.040)

[4] Zou Y, Wang A, Shi M, et al. Analysis of redox landscapes and dynamics in living cells and in vivo using genetically encoded fluorescent sensors. Nat Protoc. 2018;13(10):2362–2386. doi:10.1038/s41596-018-0042-5 (IF: 12.423)

[5] Song L, Liu Z, Hu HH, et al. Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy. Nat Commun. 2020;11(1):5842. doi:10.1038/s41467-020-19694-w (IF: 12.121)

[6] Sun X, Peng X, Cao Y, Zhou Y, Sun Y. ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling. Nat Commun. 2020;11(1):2984. doi:10.1038/s41467-020-16799-0 (IF: 12.121)

[7] Li T, Chen X, Qian Y, et al. A synthetic BRET-based optogenetic device for pulsatile transgene expression enabling glucose homeostasis in mice. Nat Commun. 2021;12(1):615. doi:10.1038/s41467-021-20913-1 (IF: 14.919)

[8] Liu Z, Chen S, Lai L, Li Z. Inhibition of base editors with anti-deaminases derived from viruses. Nat Commun. 2022;13(1):597. doi:10.1038/s41467-022-28300-0 (IF: 14.919)

🧫 2. Cancer Biology and Molecular Medicine

[1] Fan Y, Wang J, Jin W, et al. CircNR3C2 promotes HRD1-mediated tumor-suppressive effect via sponging miR-513a-3p in triple-negative breast cancer. Mol Cancer. 2021;20(1):25. doi:10.1186/s12943-021-01321-x (IF: 27.401)

[2] Xu X, Zhang J, Tian Y, et al. CircRNA inhibits DNA damage repair by interacting with host gene. Mol Cancer. 2020;19(1):128. doi:10.1186/s12943-020-01246-x (IF: 15.302)

[3] Liu W, Zhan Z, Zhang M, et al. KAT6A, a novel regulator of β-catenin, promotes tumorigenicity and chemoresistance in ovarian cancer by acetylating COP1. Theranostics. 2021;11(13):6278–6292. doi:10.7150/thno.57455 (IF: 11.556)

[4] Hao Q, Li J, Zhang Q, et al. Single-cell transcriptomes reveal heterogeneity of high-grade serous ovarian carcinoma. Clin Transl Med. 2021;11(8):e500. doi:10.1002/ctm2.500 (IF: 11.492)

[5] Zhang Y, Yu X, Sun R, et al. Splicing factor arginine/serine-rich 8 promotes multiple myeloma malignancy and bone lesion through alternative splicing of CACYBP and exosome-based cellular communication. Clin Transl Med. 2022;12(2):e684. doi:10.1002/ctm2.684 (IF: 11.492)

[6] Tang X, Deng Z, Ding P, et al. A novel protein encoded by circHNRNPU promotes multiple myeloma progression by regulating the bone marrow microenvironment and alternative splicing. J Exp Clin Cancer Res. 2022;41(1):85. doi:10.1186/s13046-022-02276-7 (IF: 11.161)

[7] Gu C, Wang Y, Zhang L, et al. AHSA1 is a promising therapeutic target for cellular proliferation and proteasome inhibitor resistance in multiple myeloma. J Exp Clin Cancer Res. 2022;41(1):11. doi:10.1186/s13046-021-02220-1 (IF: 11.161)

⚗️ 3. Biochemistry, Molecular Mechanisms & RNA Biology

[1] Zhang Q, He X, Yao S, et al. Ablation of Mto1 in zebrafish exhibited hypertrophic cardiomyopathy manifested by mitochondrion RNA maturation deficiency. Nucleic Acids Res. 2021;49(8):4689–4704. doi:10.1093/nar/gkab228 (IF: 16.971)

[2] Liang Y, Lu Q, Li W, et al. Reactivation of tumour suppressor in breast cancer by enhancer switching through NamiRNA network. Nucleic Acids Res. 2021;49(15):8556–8572. doi:10.1093/nar/gkab626 (IF: 16.971)

[3] Wu S, Cao R, Tao B, et al. Pyruvate Facilitates FACT-Mediated γH2AX Loading to Chromatin and Promotes the Radiation Resistance of Glioblastoma. Adv Sci (Weinh). 2022;9(8):e2104055. doi:10.1002/advs.202104055 (IF: 16.806)

[4] Luo Q, Wu X, Zhao P, et al. OTUD1 Activates Caspase-Independent and Caspase-Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation. Adv Sci (Weinh). 2021;8(8):2002874. doi:10.1002/advs.202002874 (IF: 16.806)

[5] Chen S, Cao X, Zhang J, Wu W, Zhang B, Zhao F. circVAMP3 Drives CAPRIN1 Phase Separation and Inhibits Hepatocellular Carcinoma by Suppressing c-Myc Translation. Adv Sci (Weinh). 2022;9(8):e2103817. doi:10.1002/advs.202103817 (IF: 16.806)

[6] Yan JM, Zhang WK, Yan LN, Jiao YJ, Zhou CM, Yu XJ. Bunyavirus SFTSV exploits autophagic flux for viral assembly and egress. Autophagy. 2022;18(7):1599–1612. doi:10.1080/15548627.2021.1994296 (IF: 16.016)

[7] Liu Z, Chen S, Xie W, et al. Versatile and efficient in vivo genome editing with compact Streptococcus pasteurianus Cas9. Mol Ther. 2022;30(1):256–267. doi:10.1016/j.ymthe.2021.06.013 (IF: 11.454)

[8] Chen P, Zhou J, Wan Y, et al. A Cas12a ortholog with stringent PAM recognition followed by low off-target editing rates for genome editing. Genome Biol. 2020;21(1):78. doi:10.1186/s13059-020-01989-2 (IF: 10.806)

🧪 4. Redox Biology & Chemical Biology

[1] Shui S, Zhao Z, Wang H, Conrad M, Liu G. Non-enzymatic lipid peroxidation initiated by photodynamic therapy drives a distinct ferroptosis-like cell death pathway. Redox Biol. 2021;45:102056. doi:10.1016/j.redox.2021.102056 (IF: 11.799)

[2] Du L, Xie Y, Zheng K, et al. Oxidative stress transforms 3CLpro into an insoluble and more active form to promote SARS-CoV-2 replication. Redox Biol. 2021;48:102199. doi:10.1016/j.redox.2021.102199 (IF: 11.799)

[3] Cen M, Ouyang W, Zhang W, et al. MitoQ protects against hyperpermeability of endothelium barrier in acute lung injury via a Nrf2-dependent mechanism. Redox Biol. 2021;41:101936. doi:10.1016/j.redox.2021.101936 (IF: 11.799)

⚛️ 5. Nanomaterials and Chemical Engineering

[1] Wu C, Wang C, Zheng J, et al. Vacuolization in Cytoplasm and Cell Membrane Permeability Enhancement Triggered by Micrometer-Sized Graphene Oxide. ACS Nano. 2015;9(8):7913–7924. doi:10.1021/acsnano.5b01685 (IF: 12.881)

4. Hieff Clone™ One Step Cloning Kit

🧬RNA Biology and Regulation

[1] Xing YH, Yao RW, Zhang Y, Guo CJ, Jiang S, Xu G, Dong J, Cui DY, Chen LL. SLERT Regulates DDX21 Rings Associated with Pol I Transcription. Cell. 2017;169(4):664-678.e16. doi:10.1016/j.cell.2017.04.011 (IF: 66.850)

[2] Liu CX, Li X, Nan F, Jiang S, Qian X, Xu W, Guan Y, Tan X, Wang D, Chen D, Liu Y, Wang F, Xu G, Cui DY, Chen LL. Structure and Degradation of Circular RNAs Regulate PKR Activation in Innate Immunity. Cell. 2019;177(4):865-880.e18. doi:10.1016/j.cell.2019.03.046 (IF: 66.850)

[3] Liu CX, Guo SK, Nan F, Xu YF, Yang L, Chen LL. RNA Circles with Minimized Immunogenicity as Potent PKR Inhibitors. Mol Cell. 2022;82(2):420-434.e6. doi:10.1016/j.molcel.2021.11.019 (IF: 16.600)

[4] Qiao HH, Wang F, Xu RG, et al. An Efficient and Multiple Target Transgenic RNAi Technique with Low Toxicity in Drosophila. Nat Commun. 2018;9(1):4160. doi:10.1038/s41467-018-06537-y (IF: 12.353)

🔥 Transcription and Stress Response

[5] Zhang H, Shao S, Zeng Y, et al. Reversible Phase Separation of HSF1 Is Required for an Acute Transcriptional Response During Heat Shock. Nat Cell Biol. 2022;24(3):340-352. doi:10.1038/s41556-022-00846-7 (IF: 28.824)

⚙️ Metabolism and Biosynthesis

[6] Li X, Zhang Y, Xu L, et al. Ultrasensitive Sensors Reveal the Spatiotemporal Landscape of Lactate Metabolism in Physiology and Disease. Cell Metab. 2023;35(1):200-211.e9. doi:10.1016/j.cmet.2022.10.002 (IF: 30.900)

[7] Guan B, Jiang YT, Lin DL, Lin WH, Xue HW. Phosphatidic Acid Suppresses Autophagy Through Competitive Inhibition by Binding GAPC and PGK Proteins. Autophagy. 2022;1-15. doi:10.1080/15548627.2022.2046449 (IF: 16.016)

[8] Yao J, He Y, Su N, et al. Developing a Highly Efficient Hydroxytyrosol Whole-Cell Catalyst by De-bottlenecking Rate-limiting Steps. Nat Commun. 2020;11(1):1515. doi:10.1038/s41467-020-14918-5 (IF: 12.121)

[9] Chen W, Yao J, Meng J, et al. Promiscuous Enzymatic Activity-aided Multiple-pathway Network Design for Metabolic Flux Rearrangement in Hydroxytyrosol Biosynthesis. Nat Commun. 2019;10(1):960. doi:10.1038/s41467-019-08781-2 (IF: 11.878)

[10] Li S, Yang X, Huang H, et al. Arabidopsis ACYL-ACTIVATING ENZYME 9 (AAE9) Encoding an Isobutyl-CoA Synthetase Is a Key Factor Connecting Branched-chain Amino Acid Catabolism with Iso-branched Wax Biosynthesis. New Phytol. 2022;233(6):2458-2470. doi:10.1111/nph.17941 (IF: 10.152)

[11] Jiang L, Wang Y, Xia A, et al. A Natural Single-nucleotide Polymorphism Variant in Sulfite Reductase Influences Sulfur Assimilation in Maize. New Phytol. 2021;232(2):692-704. doi:10.1111/nph.17616 (IF: 10.152)

🧠 Cancer and Disease Progression

[12] Xu Y, Yu Q, Wang P, et al. A Selective Small-Molecule c-Myc Degrader Potently Regresses Lethal c-Myc Overexpressing Tumors. Adv Sci (Weinh). 2022;9(8):e2104344. doi:10.1002/advs.202104344 (IF: 16.806)

[13] He X, Li Y, Chen Q, et al. O-GlcNAcylation and Stabilization of SIRT7 Promote Pancreatic Cancer Progression by Blocking the SIRT7-REGγ Interaction. Cell Death Differ. 2022;10.1038/s41418-022-00984-3 (IF: 15.828)

[14] Yu Z, Shi M, Stewart T, et al. Reduced Oligodendrocyte Exosome Secretion in Multiple System Atrophy Involves SNARE Dysfunction. Brain. 2020;143(6):1780-1797. doi:10.1093/brain/awaa110 (IF: 11.337)

🧫 Immunology and Antigen Recognition

[15] Zhou T, Zhu X, Ye Z, et al. Lupus Enhancer Risk Variant Causes Dysregulation of IRF8 Through Cooperative lncRNA and DNA Methylation Machinery. Nat Commun. 2022;13(1):1855. doi:10.1038/s41467-022-29514-y (IF: 14.919)

[16] Wu P, Zhang T, Liu B, et al. Mechano-regulation of Peptide-MHC Class I Conformations Determines TCR Antigen Recognition. Mol Cell. 2019;73(5):1015-1027.e7. doi:10.1016/j.molcel.2018.12.018 (IF: 14.548)

🧫 Archaea and Cell Division

[17] Zhang PH, Liu L, Rao X, et al. Nucleolar URB1 Ensures 3′ ETS rRNA Removal to Prevent Exosome Surveillance. Nature. 2023;615(7952):526-534. doi:10.1038/s41586-023-05767-5 (IF: 50.500)

[18] Li Y, Davidge B, Szoke D, et al. Widespread Photosynthesis Reaction Centre Barrel Proteins Are Necessary for Haloarchaeal Cell Division. Nat Microbiol. 2024;9(4):1029-1043. doi:10.1038/s41564-024-01615-y (IF: 20.500)

[19] Xiong L, Liu S, Chen S, et al. A New Type of DNA Phosphorothioation-based Antiviral System in Archaea. Nat Commun. 2019;10(1):1688. doi:10.1038/s41467-019-09390-9 (IF: 11.878)