NGS Automated Library Preparation Solution
Build a Standardized, Scalable NGS Library Prep Workflow
Integrate automated liquid handling systems, ready-to-use scripts, and automation-ready reagents into a streamlined library preparation workflow. With plate-based formulations, optimized overages, combined reactions, and master-mix designs, Yeasen helps minimize manual steps, simplify liquid handling, and improve workflow consistency from routine runs to high-throughput applications.
6 Million+
Library Prep Supply Annually
1000+
Validated Automation Scripts
1000+
Validated Index Adapters
24 Hrs
On-Site & Remote Application Support
Sample volumes climbing. Turnaround windows shrinking. Labor costs stuck. For an NGS lab, library prep is almost always the first wall you hit when scaling.
When looking into automation, four key aspects are usually taken into account:
1. Scale — Volume keeps climbing — which is more economical, headcount or throughput?
2. Quality — Machine vs. trained hands — which delivers the more consistent data?
3. Coverage — DNA, RNA, FFPE, cfDNA, single cell, long-read… can one platform really handle them all?
4. Deployment — After the instrument lands, who writes the protocols, optimizes the workflows, and stays with you for the long haul?
Built on extensive NGS library preparation expertise, automation-ready reagents, and application development capabilities, Yeasen provides a comprehensive automation solution for NGS library construction. It meets your needs for scalability, stable data, universal sample compatibility and ongoing technical support, reducing labor costs, accelerating turnaround and securing reproducible sequencing data for scaling labs.
Automated Liquid Handling Workstation
Designed for High-Throughput, Precise, and Consistent NGS Library Preparation
A fully integrated automation solution designed to standardize NGS library preparation with precise liquid handling, integrated temperature control, and built-in contamination control—supporting reliable and reproducible workflows from routine runs to high-throughput applications.
Integrated liquid handling, PCR thermocycling, and temperature control in a single workstation for streamlined sample processing.
96-channel liquid handling enables efficient, unattended processing of multiple samples with consistent performance.
UV sterilization and a laminar flow environment help minimize contamination risks throughout the workflow.
Category | Specification |
|---|---|
Throughput | 96 samples/run |
Pipetting System | Fixed 96-channel head, 1–200 μL |
Pipetting Accuracy | <±10% (2 μL); <±1% (200 μL) |
Pipetting Precision (CV) | <5% (2 μL); <1% (200 μL) |
PCR Temperature Range | 4–99°C (Accuracy: ±0.3°C; Uniformity: ±0.2°C) |
Temperature Module Range | 4–90°C (Accuracy: ±1°C; Uniformity: ±1°C) |
Laminar Flow Hood | ISO Class 5 |
UV Sterilization | >100,000 μW·s/cm² |
Robotic Arm Accuracy | ±0.1 mm |
Dimensions (W × D × H) | 740 × 1,240 × 1,110 mm |
Net Weight | 250 kg |
Beyond Automation — Full-Lifecycle Application Support
Automation is more than just equipment — successful implementation depends on continuous workflow optimization and hands-on technical expertise. We support your lab at every stage, from installation through routine operation, helping you achieve:Faster implementation. More stable operation. Easier scale-up.
On-site installation, hardware setup, and full system commissioning.
02 | Hardware & Application QCVerify instrument performance and workflow consistency before you move into routine operation.
Custom automation scripts developed, validated, and deployed for your NGS workflows.
04 | Workflow OptimizationFine-tune liquid handling, reaction conditions, purification, and library prep steps for peak performance.
05 | Ongoing Application SupportOn-site and remote troubleshooting, workflow adaptation, and support as you scale.
1,000+ Validated Scripts — Ready for Diverse NGS Applications
From research workflows to clinical sequencing, Yeasen automation solutions support a wide range of sample types and NGS applications. With 1,000+ validated scripts developed for mainstream liquid handling platforms, laboratories can accelerate automation deployment and simplify workflow implementation.
Application | Research | Clinical | Validated Automation Script |
|---|---|---|---|
WGS | ✓ | ✓ | |
mRNA-Seq | ✓ | ✓ | |
LncRNA-Seq | ✓ | ✓ | |
NIPT | ✓ | ✓ | |
PGT-A | ✓ | ✓ | |
mNGS | ✓ | ✓ | ✓ |
tNGS | ✓ | ✓ | ✓ |
16S / Metagenomics | ✓ | ✓ | ✓ |
Automation-Ready Reagents, Proven Performance
Great automation starts with the right chemistry. Yeasen's automation-ready library prep reagents are engineered around what liquid handlers do best: fast, precise, and efficient processing.
Pre-Mixed Formulations: Fewer Tubes, Fewer Steps
Every extra tube on the deck means another pipetting step, more dead-volume loss, and one more chance for contamination. Yeasen's pre-mixed master mixes tackle all three at once:
DNA Library Prep: 5+ tubes consolidated down to 3
RNA Library Prep: 10+ tubes consolidated down to 5
Fewer aspiration steps mean shorter scripts, lower tip consumption, and less reagent lost to dead volume — savings that add up on every 96-well plate. Generous reagent overages keep pipetting accurate and reliable across the entire run.
Plate-Based Formats: Load and Go
Reagents are available pre-dispensed in 96-well plate format, eliminating manual aliquoting and reagent transfer before the run. Load the plate, run the method — no pre-run reagent handling on the deck.
Proven Performance: Automated Workflows, Comparable Results
1. Consistent Libraries Across Sample Types (DNA-Seq)
Yeasen DNA library preparation delivers consistent library size and concentration across diverse sample inputs, including 293 cell gDNA, human blood gDNA, and calf gDNA. The workflow also supports both MGI UDI and Illumina UDI adapter systems under the same fragmentation conditions—enabling a standardized workflow across different sample types and sequencing platforms.
Figure 1. Library Uniformity Testing Across Different Species Using 12972ES DNA Library Prep Kit Under Identical Fragmentation Conditions.
2. Equivalent Results, Automated or Manual (mRNA-Seq)
Strand-specific mRNA libraries prepared on automated platforms match manual preparation in both yield and data quality, with a data correlation of 0.944 (N = 30,796) against reference datasets. Scale up throughput without re-validating your downstream analysis.
Figure 2. Comparison of Library Yields Between Automated and Manual Prep using 12340ES RNALibrary Prep Kit.
3. LncRNA Library Prep
<10% CV — Reliable LncRNA Library Prep at ScaleFigure 3. LncRNA NGS library preparation performance.
Know More about NGS Library Prep
Start Your Automation Journey Today
Turn “Should we automate?” into “How soon can we scale?” Choose the way that works best for your laboratory:
Get a customized automation solution based on your throughput and applications
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