Descripción
Lymphotoxin beta receptor (LTBR), previously called TNF RIII or TNF R‑related protein (TNF Rrp), is a type I transmembrane glycoprotein within the TNF receptor superfamily, designated TNFRSF3. Components of LTBR-associated signaling complexes, including TRAF2, TRAF3, NIK, IKK1, and IKK2 have been shown to participate in the coupling of LTBR to NFkappaB.
Product Information
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Synonyms |
TNFCR, TNFR3, TNFRSF3, LTBR, CD18, TNFR2-RP, TNFR-RP, LT-BETA-R, TNF-R-III, D12S370, LT-β-R |
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Species |
Human |
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Expression Region |
Gln31-Met227 |
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Accession |
P36941-1 |
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Tag |
C-hFc |
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Expression System |
HEK293 |
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Molecular Weight |
The protein has a predicted MW of 48.5 kDa. Due to glycosylation, the protein migrates to 60-70 kDa based onSDS-PAGE result. |
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Purity |
> 95% as determined by SDS-PAGE and HPLC. |
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Endotoxin Level |
< 1.0 EU per μg by the LAL method. |
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Formulation |
Lyophilized from 0.22μm filtered solution in PBS (pH 7.4). Normally8% trehalose is added as protectant before lyophilization. |
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Appearance |
Lyophilized Powder |
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Bioactivity |
【ELISA Data】Immobilized Human LIGHT, His Tag at 1 μg/ml (100 μl/Well) on the plate. Dose response curve for Human LTBR, hFc Tag with the EC50 13.8 ng/ml determined by ELISA . Immobilized Human LTBR, hFc Tag at 0.5 μg/ml (100 μl/Well) on the plate. Dose response curve for Biotinylated Anti-LTBR Antibody, hFc Tag with the EC50 20.7 ng/ml determined by ELISA. |
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Reconstitution |
Before opening, briefly centrifuge the vial. |
Product Features
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High purity
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High bioactivity
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Low endotoxin
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Excellent batch-to-batch consistency
Application
Storage
Store at -25 °C to -15 °C with a shelf life of 2 years upon receipt.
After reconstitution, store under sterile conditions at -85 °C to -65 °C for up to 3 months.
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