Activin A is a member of the TGF-β family and exhibits a wide range of biological activities, including the regulation of cell proliferation and differentiation, as well as the promotion of neuronal survival. Elevated levels of Activin A in human colorectal cancer and postmenopausal women are associated with colorectal cancer and breast cancer, respectively. The biological activity of Activin A can be neutralized by inhibin and the diffusible TGF-β antagonist follistatin. Activin A binds to two forms of Activin Receptor Type I (ActR-I-A and ActR-I-B) and two forms of Type II receptors (ActR-II-A and ActR-II-B). Activins are homodimers or heterodimers of various β subunits. They are produced as precursor proteins with an N-terminal propeptide, which is cleaved to release the C-terminal bioactive ligand.

Product Information

Performance Parameters

Storage

Store at -25 ~ -15°C. Valid for 1 year from the date of receipt. Avoid repeated freeze-thaw cycles. Centrifuge before opening the vial. It is recommended to aliquot into single-use portions for each experiment.

Product Features

High activity, high purity, low endotoxin, high stability.

Application Examples

 

Figure 1. SDS-PAGE

Human Activin A on SDS-PAGE under reduced (R) condition. The purity is greater than 95%.

 

Figure 2. Cell Based Assay

Determined by cell-based assay, Activin A protein inhibits the proliferation of mouse plasmacytoma cells MPC-11, with an ED50 of approximately 4 ng/mL.

Documents:

Manuals

91717_Manual_HB20260408