Описание
Activin A is a member of the TGF-β family and exhibits a wide range of biological activities, including the regulation of cell proliferation and differentiation, as well as the promotion of neuronal survival. Elevated levels of Activin A in human colorectal cancer and postmenopausal women are associated with colorectal cancer and breast cancer, respectively. The biological activity of Activin A can be neutralized by inhibin and the diffusible TGF-β antagonist follistatin. Activin A binds to two forms of Activin Receptor Type I (ActR-I-A and ActR-I-B) and two forms of Type II receptors (ActR-II-A and ActR-II-B). Activins are homodimers or heterodimers of various β subunits. They are produced as precursor proteins with an N-terminal propeptide, which is cleaved to release the C-terminal bioactive ligand.
Product Information
|
Product Name |
Product Number |
Specification |
|
HiActiTM Recombinant Human Activin A Protein,His Tag |
91717ES10 |
10 μg |
|
91717ES50 |
50 μg |
|
|
91717ES72 |
250 μg |
Performance Parameters
|
Synonyms |
Activin A, activin AB alpha polypeptide, erythroid differentiation factor, Erythroid differentiation protein, FSH-releasing protein, inhibin beta A chain |
|
Species |
Human |
|
Sequence |
Gly311-Ser426 |
|
Accession |
P08476 |
|
Tag |
N-His |
|
Expression System |
E.coli |
|
Molecular Weight |
Theoretical MW is approximately 20.0 kDa |
|
Purity |
> 95% as determined by SDS-PAGE |
|
Endotoxin |
Less than 1.0 EU per μg by the LAL method |
|
Formulation |
20mM NaHCO3, pH8.3 |
|
Appearance |
Liquid |
|
Bioactivity |
Determined by cell assay, Activin A inhibits the proliferation of mouse plasmacytoma cells MPC-11, with an ED50 of approximately 4ng/ml |
Storage
Store at -25 ~ -15°C. Valid for 1 year from the date of receipt. Avoid repeated freeze-thaw cycles. Centrifuge before opening the vial. It is recommended to aliquot into single-use portions for each experiment.
Product Features
High activity, high purity, low endotoxin, high stability.
Application Examples
Figure 1. SDS-PAGE
Human Activin A on SDS-PAGE under reduced (R) condition. The purity is greater than 95%.
Figure 2. Cell Based Assay
Determined by cell-based assay, Activin A protein inhibits the proliferation of mouse plasmacytoma cells MPC-11, with an ED50 of approximately 4 ng/mL.
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