Описание
Interleukin-38 (IL-38) is a cytokine with a molecular weight of 16.87 kDa, consisting of 152 amino acid residues, and belongs to the interleukin-1 (IL-1) family. IL-38 is primarily secreted by basal epithelial cells of the skin, as well as by B cells in the tonsils, spleen, and thymus. Upon binding to receptors such as IL1RAPL1 and IL-36R, IL-38 plays a crucial role in inflammation and host defense by mediating the NF-κB, AP-1, and JNK signaling pathways. Furthermore, IL-38 is involved in downregulating cell proliferation and migration, while upregulating the expression of IL-6 and IL-10.
Specifications
|
Cat.No. |
90299ES08 / 90299ES020 / 90299ES60 / 90299ES76 |
|
Size |
5 μg / 20 μg / 100 μg / 100 μg |
Components
|
Name |
90299ES08 |
90299ES20 |
90299ES60 |
90299ES76 |
|
HiActi™ Recombinant Mouse IL-38 Protein, His Tag |
5 μg |
20 μg |
100 μg |
500 μg |
Performance parameters
|
Synonyms |
interleukin 38, interleukin 1 family member 10, IL1F10, FIL1-theta, FKSG75, IL-1HY2, IL1-theta, IL1HY2, IL38 |
|
Species |
Mouse |
|
Expression Sequence |
MCSLPMARYYIIKYADQKALYTRDGQLLVGDPVADNCCAEKICTLPNRGLDRTKVPIFLGIQGGSRCLACVETEEGPSLQLEDVNIEELYKGGEEATRFTFFQSSSGSAFRLEAAAWPGWFLCGPAEPQQPVQLTKESEPSARTKFYFEQSW with polyhistidine tag at the C-terminus. |
|
Accession |
Q8WWZ1 |
|
Tag |
C-His |
|
Expression System |
E.coli |
|
Molecular Weight |
The protein has a calculated MW of 17.78 kDa. The protein migrates as 21 kDa under reducing condition |
|
Purity |
>98% as determined by SDS-PAGE. |
|
Endotoxin |
<0.1 EU per 1 μg of the protein by the LAL method. |
|
Formulation |
The protein was lyophilized from a 0.2 µm filtered solution containing 1X PBS, pH 8.0. |
|
Appearance |
Lyophilized Powder |
|
Reconstitution Instructions |
Briefly centrifuge the vial at 3000 rpm for 5 minutes before opening. It is recommended to reconstitute the lyophilized powder with sterile water to a concentration of no less than 100 μg/mL, and let it stand for at least 20 minutes to ensure complete dissolution. The reconstituted solution can be further diluted and aliquoted. When performing further dilution and aliquoting, a carrier protein (0.1% BSA, 10% FBS, or 5% HSA) must be added. For serum-free experimental requirements, a 5% trehalose solution can be used as an alternative carrier. |
Storage
Store at -25 to -15°C. Valid for 1 year from receipt. After reconstitution, store at 2 to 8°C for up to 7 days, or at -85 to -65°C for up to 3 months. To avoid repeated freeze-thaw cycles, we recommend aliquoting the protein upon first use.
Notes
1. This product is for research use only.
2. Please operate with lab coats and disposable gloves,for your safety.
Documents:
Safety Data Sheet
Manuals:
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