Anti-SN38 Mouse mAb _ 31905ES

SKU: 31905ES60

Size: 100 μg
Price:
Sale price$395.00

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Description

SN38 is the active metabolite of the chemotherapy drug irinotecan (Camptosar). It is  a topoisomerase I inhibitor, prevents the enzyme from properly resealing the DNA strands after they have been unwound, which leads to the accumulation of DNA damage.

Specifications

Cat.No.

31905ES60/31905ES80

Size

100 μg/1 mg

Source

Monoclonal anti-SN38 antibody, is produced from a hybridoma which was obtained from a mouse immunized with SN38.

Buffer

1×PBS, pH7.4.

Type

Monoclonal Antibody

Isotype

IgG1

Host

Mouse

Concentration

1 mg/mL

Purity

95% as determined by reduced SDS-PAGE

99% as determined by non-reduced SDS-PAGE

> 99% as determined by SEC-HPLC

Activity

EC50=80.5 ng/mL by ELISA

Application

ELISA

Storage

This product should be stored at -25~-15℃ for one year, do not freeze.

 Notes

  1. This product is for research use only.
  2. Please operate with lab coats and disposable gloves, for your safety.

 

Data

SDS-PAGE

Anti-SN-38 mouse mAb on SDS-PAGE under reduced condition. The purity is 95.5%

Anti-SN-38 mouse mAb on SDS-PAGE under non-reduced condition. The purity is 99.2%.

 

SEC-HPLC

The purity of Anti-SN-38 mouse mAb is 100% as determined by SEC-HPLC.

 

ELISA Data

Dose response curve shows that the EC50 of Anti-SN-38 mouse mAb is 80.5 ng/mL.

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