Description
eSpCas9 mRNA encodes an engineered Streptococcus pyogenes Cas9 (eSpCas9) protein with enhanced expression specificity. When delivered into cells or in vivo for CRISPR-based gene and cell therapies, it expresses the S. pyogenes Cas9 nuclease with more than 10-fold reduction in off-target effects, while maintaining robust on-target editing efficiency.
This mRNA features a Cap1 structure to enhance translation efficiency and protein expression levels, and includes a 100-nucleotide poly(A) tail that mimics mature eukaryotic mRNA, significantly improving its stability.
Specifications
|
Catalog Number |
17105ES60/17105ES80 |
|
Format |
100 μL /1mL |
|
Length |
4619 nt |
|
Concentration |
1 mg/mL |
|
Storage Buffer |
1 mM Sodium cjtrate, pH6.5 |
Components
|
Name |
17105ES60 |
17105ES80 |
|
eSpCas9 mRNA |
100μL |
1mL |
Storage
Store at –80°C. Valid for 2 years
Notes
1. This product is for research use only.
2. For your safety and health, please wear a lab coat and disposable gloves when handling.
3. Upon receipt, immediately store the sample at –80°C.
4. During first use, wear disposable gloves, thaw the sample on ice, and use RNase-free reagents and consumables to avoid contamination.
5. After initial thawing, briefly centrifuge the sample gently and aliquot to avoid repeated freeze-thaw cycles.
Documents:
Safety Data Sheet
Manuals
17105_Manual_Ver.EN20260120.pdf
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The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
Certain applications may require additional third-party intellectual property rights.
Yeasen is dedicated to ethical science, believing our research should address critical questions while ensuring safety and ethical standards.