Beschrijving
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is an inhibitory receptor belonging to the CD28 immunoglobulin subfamily, expressed primarily by T-cells. The family includes CD28, CTLA-4 and ICOS as well as other proteins including PD-1, BTLA and TIGIT .Its ligands, CD80 and CD86, are typically found on the surface of antigen-presenting cells and can either bind CD28 or CTLA-4, resulting in a costimulatory or a co-inhibitory response, respectively.
Specifications
|
Cat.No. |
96593ES60 / 96593ES76 |
|
Size |
100 μg / 500 μg |
Components
|
Name |
96593ES60 |
96593ES76 |
|
Recombinant Mouse CTLA-4/CD152 Protein,hFc Tag |
100 μg |
500 μg |
Performance parameters
|
Synonyms |
Celiac Disease 3,CD152,CTLA4,CTLA-4 |
|
Species |
Mouse |
|
Expression Sequence: |
Glu36-Asp161,with C-terminal Fc |
|
Accession |
P09793 |
|
Tag |
C-hFc Tag |
|
Expression System |
HEK293 |
|
Molecular Weight |
45-55 kDa (Reducing) |
|
Purity |
> 95% as determined by SDS-PAGE. |
|
Endotoxin |
<0.1 EU/μg |
|
Formulation |
PBS, pH7.4. |
|
Appearance |
Lyophilized Powder |
|
Reconstitution |
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
Storage
Store at -25°C to -15°C for 1 year upon receipt; after reconstitution under aseptic conditions, the product is stable for 7 days at 2°C to 8°C or for 3 months at -85°C to -65°C.
Product Features
High Activity & Purity, Low Endotoxin, High Lot-to-Lot Consistency.
Application Example
ELISA Data: Immobilized CTLA-4/CD152 Fc Chimera, Mouse at 10.0 μg/mL (100 μL/well) can bind B7-1/CD80 His Tag Protein, Mouse with EC50 of 2.56-3.13 μg/mL.
Notes
1. This product is for research use only.
2. Please operate with lab coats and disposable gloves, for your safety.
Documents:
Manual
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FAQ
Het product is alleen bedoeld voor onderzoeksdoeleinden en is niet bedoeld voor therapeutisch of diagnostisch gebruik bij mensen of dieren. Producten en inhoud worden beschermd door patenten, handelsmerken en auteursrechten die eigendom zijn van
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