Beschrijving
Interleukin-23 (IL-23) is a pro-inflammatory heterodimeric protein consisting of two subunits: a unique p19 subunit and a p40 subunit shared with IL-12.IL-23 is secreted by activated dendritic cells and macrophages and signals through the receptor for IL-23R in complex with IL-12Rβ 1. IL-23 has been shown to enhance the proliferation of memory T cells. It also stimulates IFN-γ production in NK cells, induces IL-17 production, and drives Th17-mediated responses.
This Recombinant Human IL-23 is supplied in liquid form, highly active, highly pure, low endotoxin, and label free.
Specification
|
Synonyms |
IL-23 p19/IL-12 p40; IL23; IL-23A; Interleukin 23; SGRF |
|
Source |
CHO |
|
Source |
Recombinant human IL-23 is composed of P40 (Ile23-Ser328) and P19 (Arg23-Pro189) subunits, which linked by GS-linker(GSGSSRGGSGSGGSGGGGSKL). |
|
Accession |
P29460(P40), AAG37232(P19) |
|
Molecular Weight |
55.0 kDa (IL-23 single chain); 36.5 kDa (p40) & 18.5 kDa (p19) |
|
Endotoxin |
< 0.01 EU/μg by the LAL method. |
|
Purity |
> 95% as determined by SDS-PAGE and HPLC. |
|
Biological Activity |
Measured by its ability to enhance IFN-gamma secretion in NK-92 human natural killer lymphoma cells. |
|
Formulation |
Lyophilized from a 0.22 μm-filtered solution containing PBS, 5% Mannitol and 0.01% Tween 80, pH 7.4. |
|
Tag |
No |
|
Physical Appearance |
Lyophilized Powder |
SEC-HPLC
The purity of Human IL-23 is greater than 95% as determined by SEC-HPLC.
Measured by its ability to enhance IFN-gamma secretion in NK-92 human natural killer lymphoma cells.
Storage
-85~-65℃ storage, valid for 1 year after receipt.
Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃.
Cautions
1. Please operate with lab coats and disposable gloves,for your safety.
2. This product is for research use only.
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FAQ
Het product is alleen bedoeld voor onderzoeksdoeleinden en is niet bedoeld voor therapeutisch of diagnostisch gebruik bij mensen of dieren. Producten en inhoud worden beschermd door patenten, handelsmerken en auteursrechten die eigendom zijn van
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