Beschrijving
Interleukin-12 (IL-12) is a potent regulator of cell-mediated immune responses, inducing the production of IFN-γ by NK and T cells.IL12 is produced by activated monocytes/macrophages, B-lymphocytes, and connective tissue-type mast cells. Among its biological activities, IL-12 promotes the growth and activity of activated NK, CD4+, and CD8+ cells and induces the development of IFN-γ-producing Th1 cells.
Recombinant Human IL-12 is a disulfide-linked p35 subunit and p40 subunit. This Recombinant Human IL-12 is supplied as a lyophilized powder with high activity, high purity, low endotoxin, and no redundant labeling.
Specification
|
Synonyms |
IL12; p70; Interleukin-12, NKSF, CTL Maturation Factor (TCMF), Cytotoxic Lymphocyte Maturation Factor (CLMF), TSF |
|
Species |
Human |
|
Source |
CHO Cells |
|
Sequence |
Recombinant human IL-12 is composed of P40(Ile23-Ser328) and |
|
Accession |
P29460(IL12P40), P29459(IL12P35) |
|
Tag |
Not |
|
Molecular Weight |
Predicted molecular |
|
Endotoxin |
≤10 EU/mg by the LAL method |
|
Purity |
≥95%, by SDS-PAGE (under reducing (R) & Non-reducing conditions, visualized by Coomassie staining) |
|
Activity |
Measured by its ability to induce Interferon gamma secretion by human natural |
|
Formulation |
Lyophilized from a 0.22 μm-filtered solution containing PBS, 5% mannitol |
|
Appearance |
Lyophilized powder |
Storage
-25 ~ -15 ° C storage, from the date of receipt of goods, the expiration date of 1 year. After re-solution, store at 2 ~8 °C, 7-10 days expiration date. After re-dissolution, -85 ~ -65 ° C storage, 6 months expiration date.
Compounding Methods
Use sterile deionized water to reconstitute freeze-dried proteins. It is recommended that proteins be divided for first use to avoid repeated freeze-thawing.
Cautions
1. Please operate with lab coats and disposable gloves,for your safety.
2. This product is for research use only.
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FAQ
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