Beschreibung
Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) is an inhibitory receptor belonging to the CD28 immunoglobulin subfamily, expressed primarily by T-cells. The family includes CD28, CTLA-4 and ICOS as well as other proteins including PD-1, BTLA and TIGIT .Its ligands, CD80 and CD86, are typically found on the surface of antigen-presenting cells and can either bind CD28 or CTLA-4, resulting in a costimulatory or a co-inhibitory response, respectively.
Specifications
|
Cat.No. |
96593ES60 / 96593ES76 |
|
Size |
100 μg / 500 μg |
Components
|
Name |
96593ES60 |
96593ES76 |
|
Recombinant Mouse CTLA-4/CD152 Protein,hFc Tag |
100 μg |
500 μg |
Performance parameters
|
Synonyms |
Celiac Disease 3,CD152,CTLA4,CTLA-4 |
|
Species |
Mouse |
|
Expression Sequence: |
Glu36-Asp161,with C-terminal Fc |
|
Accession |
P09793 |
|
Tag |
C-hFc Tag |
|
Expression System |
HEK293 |
|
Molecular Weight |
45-55 kDa (Reducing) |
|
Purity |
> 95% as determined by SDS-PAGE. |
|
Endotoxin |
<0.1 EU/μg |
|
Formulation |
PBS, pH7.4. |
|
Appearance |
Lyophilized Powder |
|
Reconstitution |
Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
Storage
Store at -25°C to -15°C for 1 year upon receipt; after reconstitution under aseptic conditions, the product is stable for 7 days at 2°C to 8°C or for 3 months at -85°C to -65°C.
Product Features
High Activity & Purity, Low Endotoxin, High Lot-to-Lot Consistency.
Application Example
ELISA Data: Immobilized CTLA-4/CD152 Fc Chimera, Mouse at 10.0 μg/mL (100 μL/well) can bind B7-1/CD80 His Tag Protein, Mouse with EC50 of 2.56-3.13 μg/mL.
Notes
1. This product is for research use only.
2. Please operate with lab coats and disposable gloves, for your safety.
Documents:
Manual
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