IL-1α and IL-1β are potent pro-inflammatory cytokines that induce a wide range of biological activities in various cell types. Two distinct types of IL-1 receptors have been identified and cloned from human and mouse cells. IL-1 Receptor Type I is an 80 kDa transmembrane protein with a well-established role in IL-1 signal transduction. IL-1 Receptor Type II is a 68 kDa membrane protein with a relatively short cytoplasmic tail that lacks signaling capability. The Type II receptor acts as a decoy target for IL-1, inhibiting IL-1 activity by preventing its binding to the Type I receptor. A soluble form of the Type II receptor is induced by anti-inflammatory agents such as glucocorticoids, IL-4, and IL-13.

This product is provided as a liquid and features high purity, high bioactivity, and low endotoxin levels.

Components

Specifications

Storage

Store at –85°C ~ –65°C. The product is stable for one year upon receipt.

Avoid repeated freeze-thaw cycles. Centrifuge the vial before opening. It is recommended to aliquot the product into single-use volumes and store the aliquots at –80°C.

Documents:

Safety Data Sheet

90278_MSDS_HB251015_EN.PDF

Manuals

90278_Manual_Ver.EN20251015.pdf