Description
Interferon-gamma (IFN-γ) is an immunomodulatory protein and a member of the interferon family. Primarily produced by activated T cells, NK cells, and certain lymphocyte subsets, IFN-γ is a cytokine with diverse biological functions. It plays a critical regulatory role in immune responses by enhancing the cytotoxic capacity of macrophages and dendritic cells, promoting their release of pro-inflammatory cytokines, and regulating the expression of antigen-presenting molecules, thereby strengthening cellular immune responses. Furthermore, IFN-γ regulates T cell differentiation and function, promotes Th1 cell development, enhances B cell class switching to IgG, and maintains the balance between cellular and humoral immunity.
Features
High Purity: >95% purity to avoid immune responses caused by residual Host Cell Proteins (HCP) or DNA.
Ultra-Low Endotoxin: <10 EU/mg to minimize the risk of fever or inflammation.
Batch-to-Batch Consistency: Ensures stability and reproducibility in cell culture applications.
Regulatory Compliance: Meets regulatory requirements for cell therapy products and supports Investigational New Drug (IND) applications.
Animal-Origin Free (AOF): Free from animal viruses, pathogens, and exogenous factor contamination, ensuring maximum safety.
Components
|
Components No. |
Name |
91224ES20 |
91224ES50 |
91224ES80 |
|
91224 |
Recombinant Human IFN-gamma GMP Protein |
20 μg |
50 μg |
1 mg |
Specifications
|
Synonyms |
Interferon-gamma,IFN-γ,IFG,IFI,IFNG,IFNgamma,IFN-gamma. |
|
Source |
E.coli. |
|
Sequence |
It contains Gln24-Gln166 |
|
Accession |
P01579 |
|
Tag |
No Tag |
|
Molecular Weight |
Approximately 16.9 kDa. |
|
Biological Activity |
Human IFN-gamma GMP Protein inhibits the proliferation of HT-29 cells.the specific activity of GMP Human IFN-gamma Protein is > 0.6×10^6 IU/mg, which is calibrated against human interferon gamma Standard (NIBSC code: 87/586). |
|
Purity |
＞95% as determined by SDS-PAGE and HPLC. |
|
Endotoxin |
＜0.01 EU/μg protein as determined by LAL method. |
|
Sterility |
Negative. |
|
Mycoplasma |
Negative. |
|
Vitro Virus |
Negative. |
|
Host Cell Protein |
Less than 0.5 ng/μg when tested by ELISA. |
|
Host Cell DNA |
Less than 20 ng/mg when tested by qPCR. |
|
Formulation |
0.22 μm filtered concentrated solution in PBS. |
|
Physical Appearance |
Lyophilized Powder |
Storage
This product should be stored at -25~-15℃ for 3 years. After reconstitution, store at -85 to -65°C. Valid for 3 months.
Figure
SDS-PAGE
Figure 1. Human IFN-gamma GMP Protein on SDS-PAGE under reduced condition. The purity is greater than 95
SEC-HPLC
Figure 2. The purity of Human IFN-gamma GMP Protein is greater than 95% as determined by SEC-HPLC.
Cell Based Assay
Figure 3. Human IFN-gamma GMP Protein inhibits the proliferation of HT-29 cells.the specific activity of GMP Human IFN-gamma Protein is > 0.6×10^6 IU/mg, which is calibrated against human interferon gamma Standard (NIBSC code: 87/586)
Documents:
Safety Data Sheet
Manuals
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The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
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