説明
Although platelets are best known for their role in hemostasis, they are also crucial in development, host defense, inflammation, and tissue repair . Many of these roles are regulated by the immune-like receptors glycoprotein VI (GPVI) and C-type lectin receptor 2 (CLEC-2), which signal through an immunoreceptor tyrosine-based activation motif (ITAM).
Specifications
|
Cat.No. |
96263ES25 / 96263ES60 / 96263ES76 |
|
Size |
25 μg / 100 μg / 500 μg |
Components
|
Name |
96263ES25 |
96263ES60 |
96263ES76 |
|
Recombinant Cynomolgus GPVI Protein,His Tag,Ultra Low Endotoxin |
25 μg |
100 μg |
500 μg |
Performance parameters
|
Synonyms |
GPVI;Gp6;Glycoprotein 6;MGC138168 |
|
Species |
Cynomolgus |
|
Expression Sequence |
Gln21-Asn251 |
|
Accession |
XP_005590417.2 |
|
Tag |
C-His |
|
Expression System |
HEK293 |
|
Molecular Weight |
The protein has a predicted MW of 26.42 kDa. Due to glycosylation, the protein migrates to 50-60 kDa based on Bis-Tris PAGE result. |
|
Purity |
> 95% as determined by SDS-PAGE and SEC-HPLC |
|
Endotoxin |
Less than 0.01 EU per μg by the LAL method. |
|
Formulation |
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). Normally 8% trehalose is added as protectant before lyophilization. |
|
Appearance |
Lyophilized Powder |
|
Biological activity |
ELISA Data 1:Immobilized Cynomolgus GPVI, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-GPVI Antibody, hFc Tag with the EC50 of 4.9 ng/ml determined by ELISA . |
|
Reconstitution Method |
Dissolve the lyophilized protein in distilled water. For vials containing 25 μg or 100 μg, we recommend reconstituting to a concentration of 0.5 mg/mL. For larger quantities (500 μg or 1 mg), a concentration of 1 mg/mL is suggested. During reconstitution, avoid vigorous vortexing or shaking. Aliquot the reconstituted solution as needed and store at -80°C. Avoid repeated freeze-thaw cycles. |
Storage
Store at -25 to -15°C for up to 1 year from the date of receipt; once reconstituted, store at -85 to -65°C where it remains stable for 3 months, avoiding repeated freeze-thaw cycles.
Notes
1. This product is for research use only.
2. Please operate with lab coats and disposable gloves,for your safety.
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