説明
PDGF-AB (Platelet-derived growth factor-AB) is an important member of the platelet-derived growth factor (PDGF) family. It belongs to heterodimeric proteins, formed by the dimerization of PDGFA and PDGFB subunits. It is a class of extracellular signaling molecules with diverse biological activities, widely involved in various physiological and pathological processes of the body. The structural core of PDGF-AB consists of two subunits (α and β) linked by disulfide bonds to form a stable protein structure. Distinct from the homodimers of the PDGF family (such as PDGF-AA and PDGF-BB), its structural characteristics determine the uniqueness of its receptor binding specificity and biological functions. It can specifically bind to PDGF receptors (PDGFR) on the cell surface and initiate downstream signaling pathways.
This product is provided as a lyophilized powder, featuring high activity, high purity, low endotoxin, high stability, and no tag.
Product Information
|
Product Information. |
Catalog Number |
Size |
|
Recombinant Human PDGF-AB Protein |
91618ES10 |
10 μg |
|
91618ES50 |
50 μg |
|
|
91618ES80 |
1 mg |
Performance Parameters
|
Synonyms |
Platelet-derived Growth Factor AB; PDGFAB |
|
Species |
Human |
|
Source |
CHO Cells |
|
Sequence |
Human PDGF-A(Ser87-Thr211)&Human PDGF-B(Ser82-Thr190) |
|
Accession |
P04085&P01127 |
|
Tag |
Tag Free |
|
Molecular Weight |
Predicted molecular mass：14.3 kDa&12.3 kDa |
|
Endotoxin |
≤10 EU/mg by the LAL method |
|
Purity |
≥95%, by SDS-PAGE (under reducing (R) & Non-reducing conditions, visualized by Coomassie staining) |
|
Activity |
Measure in a cell proliferation assay using NIH3T3 cells. The ED50 is ≤1.0 ng/mL. |
|
Formulation |
PBS, 5% Mannitol and 0.01% Tween 80, pH7.4. |
|
Appearance |
Lyophilized Powder |
Storage
Store at -25~-15°C. Valid for 1 year from the date of receipt. After reconstitution, store at 2~8°C for 7-10 days. After reconstitution, store at -85~-65°C for up to 6 months.
Reconstitution Method
Reconstitute the lyophilized protein with sterile deionized water. It is recommended to aliquot the protein upon first use to avoid repeated freeze-thaw cycles.
Notes
1. For your safety and health, please wear a lab coat and disposable gloves during operation.
2. This product is for research use only.
Documents:
91618_Manual_HB20260408
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