説明
IL-1α and IL-1β are potent pro-inflammatory cytokines that induce a wide range of biological activities in various cell types. Two distinct types of IL-1 receptors have been identified and cloned from human and mouse cells. IL-1 Receptor Type I is an 80 kDa transmembrane protein with a well-established role in IL-1 signal transduction. IL-1 Receptor Type II is a 68 kDa membrane protein with a relatively short cytoplasmic tail that lacks signaling capability. The Type II receptor acts as a decoy target for IL-1, inhibiting IL-1 activity by preventing its binding to the Type I receptor. A soluble form of the Type II receptor is induced by anti-inflammatory agents such as glucocorticoids, IL-4, and IL-13.
This product is provided as a liquid and features high purity, high bioactivity, and low endotoxin levels.
Components
|
Name |
90278ES05 |
90278ES10 |
90278ES50 |
90278ES60 |
90278ES80 |
|
Recombinant Human IL-1α Protein (HEK293) |
2 μg |
10 μg |
50 μg(5 ×10 μg) |
100 μg |
1 mg |
Specifications
|
Synonyms |
IL-3, h-IL-3, rh-IL-3, IL-3, interleukin-3, TCGF |
|
Species |
Human |
|
Source |
HEK293 cells |
|
Sequence |
Ser113–Ala271 |
|
Accession |
P01583 |
|
Tag |
No Tag |
|
Molecular Weight |
The protein has a predicted molecular weight of 18.0 kDa |
|
Endotoxin |
< 0.01 EU per μg, as determined by the LAL method |
|
Purity |
> 95%, determined by SDS-PAGE |
|
Activity |
Measured by cell proliferation assay using D10.G4.1 mouse helper T cells. The EC₅₀ for this effect is 1–6 pg/mL |
|
Formulation |
Dissolved in sterile PBS buffer |
|
Appearance |
Liquid |
Storage
Store at –85°C ~ –65°C. The product is stable for one year upon receipt.
Avoid repeated freeze-thaw cycles. Centrifuge the vial before opening. It is recommended to aliquot the product into single-use volumes and store the aliquots at –80°C.
Documents:
Safety Data Sheet
90278_MSDS_HB251015_EN.PDF
Manuals
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