شرح
GSPT1/ERF3A mediates ETF1/ERF1 delivery to stop codons: The eRF1-eRF3-GTP complex binds to a stop codon in the ribosomal A-site. GTP hydrolysis by GSPT1/ERF3A induces a conformational change that leads to its dissociation, permitting ETF1/ERF1 to accommodate fully in the A-site . Binding of eRF1, eRF3, and GTP to pretermination complexes first induces a structural rearrangement that is manifested as a 2 nucleotide forward shift of the toeprint attributed to pretermination complexes that leads to GTP hydrolysis followed by rapid hydrolysis of peptidyl tRNA.
Product Information
|
Product Information. |
Catalog Number |
Size |
|
Recombinant Human GSPT1/ERF3A Protein,GST&His Tag |
96751ES25 |
25 μg |
|
96751ES60 |
100 μg |
Product Properties
|
Synonyms |
ERF3A,FLJ39067,GST1 |
|
Species |
Human |
|
Expression Sequence |
Phe294-Asp499,with C-terminal GST&His |
|
Accession |
P15170-1 |
|
Tag |
C-GST-His Tag |
|
Expression System |
Baculovirus-Insect Cells |
|
Molecular Weight |
51 kDa (Reducing) |
|
Purity |
>85% as determined by SDS-PAGE |
|
Endotoxin |
<0.1 EU/μg |
|
Formulation |
50 mM Tris, 20 mM GSH, 5%Glycerol, pH8.0 |
|
Appearance |
Liquid |
Product Features
High activity, high purity, low endotoxin, high lot-to-lot consistency
Storage
Store at -85 ~ -65°C, valid for 1 year after receipt. Avoid repeated freeze-thaw cycles.
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