شرح
CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4) is also known as CD152 (Cluster of differentiation 152), is a protein receptor that downregulates the immune system. Humanor mouse CTLA-4 cDNA encodes 223 amino acids (aa) including a 35 aa signal sequence, a 126 aa extracellular domain (ECD) with one Ig-like V-type domain, a 21 aa transmembrane (TM) sequence, and a 41 aa cytoplasmic sequence. It is found as a covalent homodimer of 41-43 kDa.
Product Information
|
Product Information. |
Catalog Number |
Size |
|
Recombinant Cynomolgus CTLA-4/CD152 Protein,hFc Tag |
96592ES25 |
25 μg |
|
96592ES60 |
100 μg |
|
|
96592ES76 |
500 μg |
Product Properties
|
Synonyms |
CTLA-4,CD152 |
|
Species |
Cynomolgus |
|
Expression Sequence |
Ala37-Asp161,with C-terminal hIgG Fc |
|
Accession |
XP_005574071.1 |
|
Tag |
C-hFc Tag |
|
Expression System |
HEK293 |
|
Molecular Weight |
43-50 kDa (Reducing) |
|
Purity |
> 95% as determined by SDS-PAGE. |
|
Endotoxin |
< 0.1 EU/μg |
|
Formulation |
PBS, pH7.4. |
|
Appearance |
Lyophilized Powder |
|
Reconstitution Method |
Reconstitute at 0.1-1 mg/mL according to the size in ultrapure water after rapid centrifugation. |
Product Features
High activity, high purity, low endotoxin, high lot-to-lot consistency
Application Example
ELISA Data: Immobilized B7-1/CD80 His Tag,Human at 5.0 μg/mL (100 μL/well) can bind CTLA-4/CD152 Fc Chimera,Cynomolgus with EC50 of 11.18-18.05 ng/mL.
Storage
Store at -25 ~ -15°C, valid for 1 year after receipt. After reconstitution, store at 2~8°C under sterile conditions, valid for 7 days. After reconstitution, store at -85 ~ -65°C under sterile conditions, valid for 3 months.
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