شرح
C-type lectin domain family 7 member A (Clec7a, or Dectin-1) is a transmembrane protein containing an intracellular immunoreceptor tyrosine-based activation (ITAM)-like motif and an extracellular C-type lectin-like domain for recognition. Clec7a is expressed by macrophages and some other immune cells and is believed to control the innate immune responses to pathogens and the phagocytotic properties, through regulating phagocytosis and production of reactive oxygen species (ROS). Moreover, a recent study has shown that Clec7a is critical for macrophage polarization during renal interstitial fibrosis.
Product Information
|
Product Information. |
Catalog Number |
Size |
|
Recombinant Human CLEC7A Protein,hFc Tag |
96588ES60 |
100 μg |
|
96588ES76 |
500 μg |
Product Properties
|
Synonyms |
BGR,CANDF4,CD369,CLECSF12,DECTIN1,SCARE2 |
|
Species |
Human |
|
Expression Sequence |
Thr66-Met247,with C-terminal Human IgG Fc |
|
Accession |
Q9BXN2 |
|
Tag |
C-hFc Tag |
|
Expression System |
HEK293 |
|
Molecular Weight |
55-72kDa (Reducing) |
|
Purity |
> 95% as determined by SDS-PAGE. |
|
Endotoxin |
< 0.1 EU/μg |
|
Formulation |
PBS, pH7.4. |
|
Appearance |
Lyophilized Powder |
|
Reconstitution Method |
Reconstitute at 0.1-1 mg/mL according to the size in ultrapure water after rapid centrifugation. |
Product Features
High activity, high purity, low endotoxin, high lot-to-lot consistency
Storage
Store at -25 ~ -15°C, valid for 1 year after receipt. After reconstitution, store at 2~8°C under sterile conditions, valid for 7 days. After reconstitution, store at -85 ~ -65°C under sterile conditions, valid for 3 months.
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