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PD-L1 is one of the ligands for PD-1 and plays a critical role in the regulation of T cell immunity. The PD-L1 protein belong to the B7 family of immune regulatory molecules. PD-L1 provides a molecular stop signal to the adaptive immune system helping to distinguish between self and foreign antigens. PD-L1 also plays a role in the development of immune tolerance by promoting T cell anergy and enhancing regulatory T cell development.
Specifications
|
Synonyms |
PD-L1,CD274,B7-H1,PDCD1L1,PDCD1LG1,PDL1 |
|
Uniprot No. |
Q9NZQ7 |
|
Source |
Recombinant Human PDL1 Protein is expressed from HEK293 Cells with His tag at the C-terminal. It contains Phe 19- Thr 239. |
|
Molecular Weight |
The protein has a predicted MW of 26 kDa. And it migrates as an approximately 33 kDa under reducing condition in SDS-PAGE due to glycosylation. |
|
Purity |
> 95% as determined by SDS-PAGE |
|
Endotoxin |
<1 EU per 1μg of the protein by the LAL method. |
|
Formulation |
Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4). |
|
Reconstitution |
Centrifuge tubes before opening. The concentration of protein solution used for lyophilization is generally 1mg/mL. Dissolve lyophilized protein with sterile water to ensure the concentration is greater than 100 μg/mL. |
Storage
The product should be stored at -25~-15℃ for 1 year from date of receipt.
2-7 days, 2 ~8 °C under sterile conditions after reconstitution.
3 months, -25~-15℃ under sterile conditions after reconstitution.
Recommend to aliquot the protein into smaller quantities when first used and avoid repeated freeze-thaw cycles.
Note
1.Please operate with lab coats and disposable gloves for your safety.
2.This product is for research use only.
Product Data
SDS-PAGE
Bioactivity -SPR Data
Storage
FAQ
Citations
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The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
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