شرح
IInterleukin-9 (IL-9) is primarily expressed by activated T cells. IL-9 exerts its biological effects by binding to its specific receptor, IL-9Rα. It promotes Th2-type immune responses and is involved in the pathogenesis of allergic diseases, such as asthma and atopic dermatitis. Furthermore, IL-9 supports the growth of helper T cells in an IL-2 and IL-4-independent manner, and promotes the proliferation of mast cells, erythroid progenitor cells, and other cell types.
Components
|
Name |
90372ES10 |
90372ES50 |
90372ES80 |
|
Recombinant Human IL-9 GMP Protein |
10 μg |
50 μg |
1 mg |
Performance parameters
|
Synonyms |
Interleukin-9, IL-9, Cytokine P40 |
|
Source |
Human IL-9 Protein is expressed from CHO Cells. |
|
Sequence |
Gln 19 - Ile 144 |
|
Molecular Weight |
The protein has a calculated MW of 14.1 kDa. The protein migrates as 40 kDa±3 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation. |
|
Accession |
P15248 |
|
Biological Activity |
The ED50 as determined by the dose-dependent stimulation of the proliferation of human M07e cells is ≤ 2.0 ng/ml. |
|
Purity |
＞95% as determined by SDS-PAGE. |
|
Endotoxin |
＜0.01 EU/μg protein as determined by LAL method. |
|
Sterility |
Negative. |
|
Mycoplasma |
Negative. |
|
Vitro Virus |
Negative. |
|
Host Cell Protein |
Less than 0.5 ng/μg when tested by ELISA. |
|
Host Cell DNA |
Less than 20 ng/mg when tested by qPCR. |
|
Formulation |
Lyophilized from 0.22μm filtered solution in PBS, pH7.4 with trehalose as protectant. |
|
Physical Appearance |
Lyophilized Powder |
Storage
This product should be stored at -25 ~ -15°C for 2 years. After reconstitution, store at -85 to -65°C. Valid for 3 months.
Figure
1. SDS- PAGE
Figure 1. Human IL-9 GMP Protein on SDS-PAGE under reduced condition. The purity is greater than 95%.
2.Cell Based Assay
Figure 2. The ED50 as determined by a cell proliferation assay using human M07e cells is less than 2.0 ng/mL.
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