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DM1, also known as maytansine, is a microtubulin inhibitor, potentially conjugated with monoclonal antibodies to form antibody-drug conjugates(ADCs). DM1 as the toxin component of ADCs, exhibits strong anti-tumor activity by inhibiting cell division and inducing apoptosis.
Specifications
|
Cat.No. |
31901ES60/31901ES80 |
|
Size |
100 μg/1 mg |
|
Source |
Monoclonal anti-DM1 antibody, is produced from a hybridoma which was obtained from a mouse immunized with DM-1. |
|
Buffer |
1×PBS, pH7.4. |
|
Type |
Monoclonal Antibody |
|
Isotype |
IgG1 |
|
Host |
Mouse |
|
Concentration |
1 mg/mL |
|
Purity |
＞94% as determined by reduced SDS-PAGE ＞97% as determined by non-reduced SDS-PAGE > 98% as determined by SEC-HPLC |
|
Activity |
EC50=8.6 ng/mL by ELISA |
|
Application |
ELISA |
Notes
- This product is for research use only.
- Please operate with lab coats and disposable gloves, for your safety.
Data
SDS-PAGE
Anti-DM1 mouse mAb on SDS-PAGE under reduced condition. The purity is 93.4%；
Anti-DM1 mouse mAb on SDS-PAGE under non-reduced condition. The purity is 98.0%.
SEC-HPLC
The purity of Anti-DM1 mouse mAb is 96.8% as determined by SEC-HPLC.
ELISA Data
Dose response curve shows that the EC50 of Anti-DM1 mouse mAb is 8.6 ng/mL.
Storage
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The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
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