وصف
The Human Naïve T Cell Expansion Cytokine Set contains recombinant human IL-2, recombinant human IL-7, and recombinant human IL-15. These three cytokines are essential key growth factors for the culture of Naïve T cells. This combination minimizes the generation of terminally differentiated effector T cells and exhausted T cells, and the expanded cells possess stronger self-renewal capabilities and in vivo persistence.
IL-2 is a potent T cell growth factor that drives clonal expansion. On the basis of IL-7/IL-15, it provides additional proliferation signals.
IL-7 is a survival factor, and its main function is to maintain T cell basal metabolism and survival. It is crucial for Naïve T cells and T memory stem cells. It can drive homeostatic proliferation and help maintain the Naïve/T memory stem cell phenotypes such as CD45RA, CCR7, and CD62L.
IL-15 mainly functions to promote slow, homeostatic proliferation and promotes basal proliferation without driving terminal differentiation. It enhances CD8⁺ T cell persistence.
IL-7+IL-15: Mimics homeostatic "tonic" signals, maintains cell viability, promotes slow and steady division, and maintains the naïve phenotype. Low-dose IL-2: Provides stronger proliferation signals upon activation (via TCR/CD3/CD28), and the low dose can reduce cell differentiation.
Product Information
|
Product Information. |
Catalog Number |
Size |
|
Human Naïve T Expansion Cytokine Set |
92647ES10 |
10 μg |
|
92647ES50 |
50 μg |
|
|
92647ES60 |
100 μg |
Components
|
Component Cat No. |
Component Name |
92647ES10 |
92647ES50 |
92647ES60 |
Quantity |
|
92647ES-A |
Human IL-2 Protein |
10 μg |
50 μg |
100 μg |
1 |
|
92647ES-B |
Human IL-7 Protein |
10 μg |
50 μg |
100 μg |
1 |
|
92647ES-C |
Human IL-15 Protein |
10 μg |
50 μg |
100 μg |
1 |
Product Includes
|
Component Cat No. |
Product Name |
Source |
Appearance |
|
90213ES |
Human IL-2 Protein |
E.coli |
Lyophilized powder |
|
90188ES |
Human IL-7 Protein |
E.coli |
Lyophilized powder |
|
90113ES |
Human IL-15 Protein |
E.coli |
Lyophilized powder |
Reconstitution Method
|
Component Name |
Reconstitution Method |
|
Human IL-2 Protein |
Before opening, centrifuge first to bring the contents to the bottom. Reconstitute with sterile water to a concentration of 0.1-1.0 mg/mL; further dilution can be performed according to subsequent experiments. For long-term storage, it is recommended to add carrier protein (0.1% BSA) to the dilution buffer; aliquot into single-use amounts, store frozen at -80°C, and avoid repeated freeze-thaw cycles. |
|
Human IL-7 Protein |
|
|
Human IL-15 Protein |
Storage
|
Component Name |
Storage Conditions |
|
Human IL-2 Protein |
Store at -25 ~ -15°C, valid for 1 year from the date of receipt. After reconstitution, store at 2~8°C under sterile conditions, valid for 7 days. After reconstitution, store at -85 ~ -65°C under sterile conditions, valid for 3 months. |
|
Human IL-7 Protein |
|
|
Human IL-15 Protein |
Specifications
|
Parameter |
Specification |
|
Source |
Human |
|
Tag |
No Tag |
|
Expression System |
E. coli |
|
Purity |
> 95% as determined by SDS-PAGE and HPLC. |
|
Endotoxin |
< 1.0 EU/μg by the LAL method. |
|
Formulation |
Lyophilized from a 0.2 μm filtered concentrated solution in PBS, pH 7.4. |
|
Appearance |
Lyophilized Powder |
Notes
1. For your safety and health, please wear a lab coat and disposable gloves during operation.
2. This product is for research use only.
Documents:
Manuals:
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The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
Certain applications may require additional third-party intellectual property rights.
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