وصف
CHIR-99021 is an amino pyrimidine derivative and a potent inhibitor of GSK-3α (IC50: 10 nM) and GSK-3β (IC50: 6.7 nM). CHIR-99021 has over 500 times selectivity for GSK-3 compared to the closest homologs CDC2, ERK2, and other protein kinases. CHIR-99021 activates the Wnt/β-catenin signaling pathway and induces cardiomyocyte differentiation of embryonic stem cells.
Features
Purity≥98%
Standardized production, using factory mass production mode
Specifications
|
Cat.No. |
53003ES05/53003ES08/53003ES10 |
|
Size |
2 mg/5 mg/10 mg |
|
Synonym |
CT99021；CHIR99021 |
|
Target |
GSK-3α；GSK-3β |
|
CAS No. |
252917-06-9 |
|
Molecular formula |
C22H18Cl2N8 |
|
Molecular weight |
465.34 |
|
Appearance |
solid powder |
|
Purity |
≥98% |
|
Solubility |
soluble in DMSO |
|
Structure |
 |
Components
|
Components No. |
Name |
53003ES05 |
53003ES08 |
53003ES10 |
|
53003 |
CHIR-99021 |
2 mg |
5 mg |
10 mg |
Shipping and Storage
The CHIR-99021 products should be stored at -15～-25℃ for 2 years. Avoid repeated freeze-thaw cycles.
Documents:
Safety Data Sheet
Manuals
Payment & Security
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The product is for research purposes only and is not intended for therapeutic or diagnostic use in humans or animals. Products and content are protected by patents, trademarks, and copyrights owned by Yeasen Biotechnology. Trademark symbols indicate the country of origin, not necessarily registration in all regions.
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