RNA enzymes exist widely in the environment, and are easy to degrade RNA in fresh samples of animal and plant tissues, blood, body fluids, etc., so that researchers need to do liquid nitrogen quick-freeze or immediately purify RNA after collecting fresh samples, which brings a lot of inconvenience to researchers' outdoor work.

RNAsafe Tissue Stabilizer is specially developed to stabilize and protect RNA in collected samples as a non-toxic solution that can rapidly penetrate tissues and inactivate endogenous RNase.

Features

• Effectiveness—stabilize RNA for 1 day at 37°C, 1 week at 25°C, 1 month at 4°C, or indefinitely at -20°C/-80°C.
• Simplicity—a single reagent that immediately inactivates RNases and stabilizes RNA within tissues or cells
• Convenience—no need to freeze samples in liquid nitrogen or rush samples back to the lab freezer
• Mobility—perfect for tissue collection, for example, Animal Tissues, Plant Tissues, Cells, White Blood Cells,Yeast etc.
• Versatility—compatible with many RNA isolation procedures, including most RNA isolation kits

Applications

RNAsafe Tissue Stabilizer has been tested on a variety of mammalian tissues, plants, E. coli, Xenopus, fish, and Drosophila. It is ideal for:
• Protecting RNA integrity in tissues rich in RNases
• Collecting samples from different time points without having to process the samples from each time point immediately
• Shipping samples on wet ice or even at room temperature if shipped overnight

Specifications

Components

Shipping and Storage

This product should be transport at room temperature,and stored at room temperature for 5 years.

Figures

Documents:

Safety Data Sheet

10604_MSDS_HB20260611

Manuals

10604_Manual_HB20260608

FAQ：

Q1: I plan to add this solution to frozen tissues and store them for 2-3 months. Is it okay to store them at -80°C after adding the solution?

A1: It is not recommended for use with frozen tissues. If you need to preserve RNA integrity in frozen tissues, please use our RNAsafe-ICE Frozen Animal/Plant Tissue RNA Stabilization-Transition Solution (Cat. No. 10605ES60). This product can restore frozen tissues to a state suitable for homogenization and subsequent RNA extraction. It also allows for long-term storage at -20°C while maintaining RNA stability.

Q2: How long can cells or tissues be stored?

A2: They are stable for 1 day at 37°C, 1 week at 25°C, 1 month at 4°C, and can be stored long-term at -20°C or -80°C.

Q3: After processing fresh cells or tissues, can they be directly frozen at -20°C or -80°C？

A3:They need to be fully infiltrated at 4°C before freezing and storage. Overnight infiltration is recommended.

Citations & References

[1] Li Y, Zhang X, Wang C, et al. Demethylenetetrahydroberberine alleviates nonalcoholic fatty liver disease by inhibiting the NLRP3 inflammasome and oxidative stress in mice. Life Sci. 2021;281:119778. doi:10.1016/j.lfs.2021.119778. (IF: 5.037)

[2] Li Y, Zhang X, Wang C, et al. DMTHB ameliorates memory impairment in Alzheimer's disease mice through regulation of neuroinflammation. Neurosci Lett. 2022;785:136770. doi:10.1016/j.neulet.2022.136770. (IF: 3.197)

[3] Liu D, Ding L, Yang X, Zhang X, Xiong X, Xiong Y, Li J, Gerong D, Silang L, Li C, Lan D, Yin S. Identification and Functional Analysis of miRNAs in the Cauda Epididymis of Yak and Cattle. Animals. 2026;16(3):492. doi:10.3390/ani16030492. (IF: 3.0)Citations & References