描述
Interleukin-23 (IL-23) is a pro-inflammatory heterodimeric protein consisting of two subunits: a unique p19 subunit and a p40 subunit shared with IL-12.IL-23 is secreted by activated dendritic cells and macrophages and signals through the receptor for IL-23R in complex with IL-12Rβ1. IL-23 has been shown to enhance the proliferation of memory T cells.IL-23 also stimulates the production of IFN-γ in NK cells, induces IL-17 production, and drives Th17-mediated responses.
This Recombinant Human IL-23 is supplied in liquid form and is highly active, highly pure, low endotoxin, and label free.
Specification
|
Synonyms |
Interleukin-23;IL-23 p19/IL-12 p40; IL23; IL-23; IL-23A; IL-23-A; IL-23p19; IL-23p19/IL-12p40; IL23P19P1;NKSF2;IL-12B&IL-23A |
|
Source |
HEK293 |
|
Sequence |
p40 (Met1-Ser335) & p19 (Val22-Ala196) |
|
Accession |
P43432 (p40) & Q9EQ14 (p19) |
|
Molecular Weight |
Predicted Moleucular weight: 57.9 kDa |
|
Endotoxin |
< 0.01 EU/μg by the LAL method. |
|
Purity |
> 95%，determined by SDS-PAGE |
|
Biological Activity |
Measured by its ability to induce IL-17 secretion by mouse splenocytes. The EC50 for this effect is 0.005-0.25 ng/mL. |
|
Formulation |
Dissolved in sterile PBS buffer. |
|
Tag |
Not |
|
Physical Appearance |
Fluids |
|
concentration |
0.2 mg/mL |
Storage
-85~-65℃ storage, valid for 1 year after receipt.
Avoid repeated freezing and thawing, centrifuge before opening the vial. It is recommended to aliquot for one experimental use, after aliquoting, freeze at -80℃.
Cautions
1. Please operate with lab coats and disposable gloves,for your safety.
2. This product is for research use only.
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本產品僅用於研究目的，不用於人類或動物的治療或診斷用途。產品和內容受以下公司的專利、商標和版權保護：
某些應用程式可能需要額外的第三方智慧財產權。