{"product_id":"92140","title":"Proteína NRG1-BETA1 humana recombinante _ 92711es","description":"\u003cdiv class=\"Section0\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eA família neuregulina de glicoproteínas estruturalmente relacionadas compreende produtos de quatro genes distintos, mas relacionados, Nrg-1, Nrg-2, Nrg-3 e Nrg-4. Por meio de splicing alternativo ou do uso de promotores alternativos, NRG-1 demonstrou codificar mais de 14 proteínas solúveis ou transmembrana. O domínio extracelular das isoformas transmembrana NRG1 pode ser clivado proteoliticamente para liberar fatores de crescimento solúveis. Todas as isoformas NRG1 contêm um domínio semelhante a EGF (variante de splicing alfa ou beta que diferem em sua região C-terminal) que é necessário para sua ligação direta às tirosina quinases receptoras ErbB3 ou ErbB4. O ErbB3 ou ErbB4 subsequentemente recruta e heterodimeriza com ErbB2, resultando em fosforilação de tirosina e sinalização NRG1. As isoformas NRG1 podem ser classificadas em três subtipos principais. Os NRG1s do tipo I (Neu Differentiation Factor, NDF; Heregulin, HRG; Acetylcholine Receptor Inducing Activity, ARIA) e do tipo II (Glial Growth Factor, GGF) têm um domínio semelhante à imunoglobulina (Ig) N-terminal ao domínio semelhante ao EGF. Os NRG1s do tipo I diferem dos NRG1s do tipo II por terem um domínio rico em glicosilação entre os domínios semelhantes à Ig e ao EGF. Os NRG1s do tipo III (Sensory and Motor Neuron-Derived Factor) não têm o domínio semelhante à Ig, mas têm um domínio rico em cisteína (CRD). As isoformas do NRG1 mostram padrões de expressão espacial e temporal distintos. Essas proteínas desempenham papéis importantes durante o desenvolvimento do sistema nervoso e do coração. Foi demonstrado que elas regulam a expressão seletiva de receptores de neurotransmissores em neurônios e na junção neuromuscular, e promovem a diferenciação e o desenvolvimento de células de Schwann a partir de células-tronco da crista neural. Também foi demonstrado que os NRG1s estão envolvidos no estabelecimento da linhagem oligodendroglial.\u003c\/span\u003e\u003c\/p\u003e  \u003cp align=\"justify\"\u003e  \u003c\/p\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eProduto \u003c\/b\u003e\u003cb\u003ePropriedades\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003cp align=\"justify\"\u003e  \u003c\/p\u003e  \u003cdiv class=\"tableResponsive\"\u003e  \u003ctable width=\"100%\" class=\"Table\"\u003e  \u003ctbody\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eSinônimos\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eÁRIA; GGF; GGF2; HGL; HRG; Neuregulina-1 beta 1; NRG1 beta 1\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eAdesão\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eQ02297\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eIdentificação genética\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e3084\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eFonte\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eDerivado de E. coli NRG1-β1 humano, Ser177-Glu241.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003ePeso molecular\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eAproximadamente 7,5 kDa.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eSequência AA\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eSHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eMarcação\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eNenhum\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eAparência física\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003ePó branco liofilizado (liofilizado) filtrado estéril.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003ePureza\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u0026gt; 97 % por análises de SDS-PAGE e HPLC.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eAtividade Biológica\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eO DE\u003csub\u003e50\u003c\/sub\u003e conforme determinado por um ensaio de proliferação celular usando células MCF-7 humanas livres de soro é inferior a 0,5 ng\/mL, correspondendo a uma atividade específica de \u0026gt; 2,0 × 10\u003csup\u003e6\u003c\/sup\u003e\u003csup\u003e  \u003c\/sup\u003eUI\/mg. Totalmente biologicamente ativo quando comparado ao padrão. \u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eEndotoxina\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u0026lt; 0,1 UE por 1μg da proteína pelo método LAL.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eFormulação\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eLiofilizado de uma solução filtrada de 0,2 μm em 1 × PBS, pH 7,4, com 5% de trealose.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003c\/tbody\u003e  \u003c\/table\u003e  \u003c\/div\u003e  \u003c\/div\u003e  \u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e  \u003cdiv class=\"tableResponsive\"\u003e  \u003ctable width=\"100%\" class=\"Table\"\u003e  \u003ctbody\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eReconstituição\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eRecomendamos que este frasco seja centrifugado brevemente antes de ser aberto para levar o conteúdo ao fundo. Reconstitua em água destilada estéril ou tampão aquoso contendo 0,1% BSA para uma concentração de 0,1-1,0 mg\/mL. As soluções de estoque devem ser divididas em alíquotas de trabalho e armazenadas a ≤ -20\u003cspan face=\"Times New Roman, Times, serif\" style=\"font-family: 'Times New Roman', Times, serif;\"\u003e°C\u003c\/span\u003e. Diluições adicionais devem ser feitas em soluções tamponadas apropriadas.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003c\/tbody\u003e  \u003c\/table\u003e  \u003c\/div\u003e  \u003cp align=\"justify\"\u003e  \u003c\/p\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eS\u003c\/b\u003e\u003cb\u003ehippie\u003c\/b\u003e\u003cb\u003e e S\u003c\/b\u003e\u003cb\u003earmazenamento\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003cp align=\"justify\"\u003e  \u003c\/p\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eOs produtos são enviados com bolsa de gelo e podem ser armazenados em -20\u003cspan face=\"Times New Roman, Times, serif\" style=\"font-family: 'Times New Roman', Times, serif;\"\u003e°C\u003c\/span\u003e para 1 ano.\u003c\/span\u003e\u003c\/p\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e1 mês, 2 a 8 °C em condições estéreis após reconstituição.\u003c\/span\u003e\u003c\/p\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e3 meses, -20 a -70 °C sob condições estéreis após reconstituição.\u003c\/span\u003e\u003c\/p\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eRecomenda-se dividir a proteína em quantidades menores quando usada pela primeira vez e evitar ciclos repetidos de congelamento e descongelamento.\u003c\/span\u003e\u003c\/p\u003e  \u003cp align=\"justify\"\u003e  \u003c\/p\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eCuidado\u003c\/b\u003e\u003cb\u003ee\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003cp align=\"justify\"\u003e  \u003c\/p\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cspan face=\"Times New Roman, Times, serif\" style=\"font-family: 'Times New Roman', Times, serif;\"\u003e1.\u003c\/span\u003eEvite ciclos repetidos de congelamento e descongelamento.\u003c\/span\u003e\u003c\/p\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cspan face=\"Times New Roman, Times, serif\" style=\"font-family: 'Times New Roman', Times, serif;\"\u003e2.\u003c\/span\u003ePara sua segurança e saúde, use jalecos e luvas descartáveis ​​durante a operação.\u003c\/span\u003e\u003c\/p\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cspan face=\"Times New Roman, Times, serif\" style=\"font-family: 'Times New Roman', Times, serif;\"\u003e3.\u003c\/span\u003eSomente para uso em pesquisa!\u003c\/span\u003e\u003c\/p\u003e","brand":"Yeasen","offers":[{"title":"10 ug","offer_id":53302321414462,"sku":"92140ES10","price":75.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53302321447230,"sku":"92140ES60","price":390.0,"currency_code":"USD","in_stock":true},{"title":"500 ug","offer_id":53302321479998,"sku":"92140ES76","price":940.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0803\/9419\/1166\/files\/92140_06e8840e-75da-4f92-a9e4-110789677321.png?v=1776042824","url":"https:\/\/www.yeasenbio.com\/pt\/products\/92140","provider":"Yeasen - Leading Innovation in Molecular Enzymes and Reagents","version":"1.0","type":"link"}