{"product_id":"90906","title":"Crescimento humano recombinante regulamentou proteína-gama\/cxcl3 (Human Gro-γ\/CXCL3) _ 90906es","description":"\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eGRO alfa humano, GRO beta (MIP-2 alfa) e GRO gama (MIP-2 beta) são produtos de três genes humanos distintos e não alélicos. GRO beta e GRO gama compartilham 90% e 86% de homologia de sequência de aminoácidos, respectivamente, com GRO alfa. Todos os três GROs humanos são membros da subfamília alfa (CXC) de quimiocinas e são considerados homólogos de KC murino e MIP-2.\u003c\/span\u003e\u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eOs três cDNAs GRO codificam 107 proteínas precursoras de aminoácidos das quais os resíduos de 34 aminoácidos N-terminais são clivados para gerar os GROs maduros. Não há potenciais sítios de glicosilação ligados a N nas sequências de aminoácidos. A expressão de GRO é induzível por soro ou PDGF e\/ou por uma variedade de mediadores inflamatórios, como IL-1 e TNF, em monócitos, fibroblastos, melanócitos e células epiteliais. Em certas linhagens de células tumorais, GRO é expressa constitutivamente.\u003c\/span\u003e\u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eSimilar a outras quimiocinas alfa, as três proteínas GRO são potentes atrativos e ativadores de neutrófilos. Além disso, essas quimiocinas também são ativas em relação aos basófilos. Todas as três GROs podem se ligar com alta afinidade ao receptor IL-8 tipo B.\u003c\/span\u003e\u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e  \u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eProduto \u003c\/span\u003e\u003c\/strong\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003ePropriedades\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003cdiv class=\"tableResponsive\" data-mce-fragment=\"1\"\u003e  \u003ctable width=\"100%\" cellspacing=\"0\" data-mce-fragment=\"1\"\u003e  \u003ctbody data-mce-fragment=\"1\"\u003e  \u003ctr class=\"firstRow\" data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eSinônimos\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eGRO-gama, MIP2-beta\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAdesão\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eP19876\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eIdentificação genética\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e2921\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eFonte\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eHumano derivado de E. coli \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003eGRO-γ\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e,Ala35-Asn107.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003ePeso molecular\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAproximadamente 7,9 kDa\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eSequência AA\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eASVVTELRCQ CLQTLQGIHL KNIQSVNVRS PGPHCAQTEV IATLKNGKKA CLNPASPMVQ KIIEKILNKG STN\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eMarcação\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eNenhum\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAparência física\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003ePó branco liofilizado (liofilizado) filtrado estéril.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003ePureza\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u0026gt; 97% por análises de SDS-PAGE e HPLC.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAtividade Biológica\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eTotalmente biologicamente ativo quando comparado ao padrão. A atividade biológica determinada por um bioensaio de quimiotaxia usando células humanas 293 transfectadas com CXCR2 humano está em uma faixa de concentração de 10-100 ng\/m\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003eeu\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eEndotoxina\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u0026lt;  1 UE por 1μg de proteína pelo método LAL.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eFormulação\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eLiofilizado de uma solução concentrada filtrada de 0,2 µm em 20 mM PB, pH 7,4, 50 mM NaCl.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eReconstituição\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eRecomendamos que este frasco seja centrifugado brevemente antes de ser aberto para levar o conteúdo ao fundo. Reconstitua em água destilada estéril ou tampão aquoso contendo 0,1% de BSA para uma concentração de 0,1-1,0 mg\/mL.As soluções de estoque devem ser divididas em alíquotas de trabalho e armazenadas a ≤ -20°C. Diluições adicionais devem ser feitas em soluções tamponadas apropriadas.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003c\/tbody\u003e  \u003c\/table\u003e  \u003c\/div\u003e  \u003cp data-mce-fragment=\"1\"\u003e  \u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eEnvio e armazenamento\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eOs produtos são enviados com bolsa de gelo e podem ser armazenados em \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e-\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e20\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e℃ a -80℃\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e para \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e1\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e ano.\u003c\/span\u003e\u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eRecomenda-se dividir a proteína em quantidades menores quando usada pela primeira vez\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e  \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003ee evitar congelamento repetido\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003edescongelamento \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003eciclos.\u003c\/span\u003e\u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e  \u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eCuidados\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e1. Evite ciclos repetidos de congelamento e descongelamento.\u003c\/span\u003e\u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e2. Para sua segurança e saúde, use jalecos e luvas descartáveis ​​para a operação.\u003c\/span\u003e\u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e3. Somente para uso em pesquisa.\u003c\/span\u003e\u003c\/p\u003e","brand":"Yeasen","offers":[{"title":"100 ug","offer_id":53213668114750,"sku":"90906ES60","price":565.0,"currency_code":"USD","in_stock":true},{"title":"500 ug","offer_id":53213668147518,"sku":"90906ES76","price":1410.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0803\/9419\/1166\/products\/20220513162505336_ae34779f-37e4-4793-819f-f925c62d95a5.jpg?v=1708077079","url":"https:\/\/www.yeasenbio.com\/pt\/products\/90906","provider":"Yeasen - Leading Innovation in Molecular Enzymes and Reagents","version":"1.0","type":"link"}