{"product_id":"92140","title":"Proteina ricombinante nrg1-beta1 _ 92711es","description":"\u003cdiv class=\"Section0\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eLa famiglia delle neureguline di glicoproteine ​​strutturalmente correlate comprende prodotti di quattro geni distinti ma correlati, Nrg-1, Nrg-2, Nrg-3 e Nrg-4. Attraverso lo splicing alternativo o l'uso di promotori alternativi, Numero-1 ha dimostrato di codificare più di 14 proteine ​​solubili o transmembrana. Il dominio extracellulare delle isoforme transmembrana NRG1 può essere scisso proteoliticamente per rilasciare fattori di crescita solubili. Tutte le isoforme NRG1 contengono un dominio simile a EGF (variante di splicing alfa o beta che differisce nella sua regione C-terminale) che è necessario per il loro legame diretto alle tirosin-chinasi del recettore ErbB3 o ErbB4. Successivamente ErbB3 o ErbB4 recluta ed eterodimerizza con ErbB2, con conseguente fosforilazione della tirosina e segnalazione NRG1. Le isoforme NRG1 possono essere classificate in tre sottotipi principali. Gli NRG1 di tipo I (Neu Differentiation Factor, NDF; Heregulin, HRG; Acetylcholine Receptor Inducing Activity, ARIA) e di tipo II (Glial Growth Factor, GGF) hanno un dominio simile all'immunoglobulina (Ig) N-terminale al dominio simile all'EGF. Gli NRG1 di tipo I differiscono dagli NRG1 di tipo II perché hanno un dominio ricco di glicosilazione tra il dominio simile all'IGF e quello simile all'EGF. Gli NRG1 di tipo III (Sensory and Motor neuron-Derived Factor) non hanno il dominio simile all'IGG ma hanno invece un dominio ricco di cisteina (CRD). Gli isoformi di NRG1 mostrano distinti modelli di espressione spaziale e temporale. Queste proteine ​​svolgono ruoli importanti durante lo sviluppo sia del sistema nervoso che del cuore. È stato dimostrato che regolano l'espressione selettiva dei recettori dei neurotrasmettitori nei neuroni e nella giunzione neuromuscolare e promuovono la differenziazione e lo sviluppo delle cellule di Schwann dalle cellule staminali della cresta neurale. È stato anche dimostrato che gli NRG1 sono coinvolti nella formazione della linea oligodendrogliale.\u003c\/span\u003e\u003c\/p\u003e  \u003cp align=\"justify\"\u003e  \u003c\/p\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eProdotto \u003c\/b\u003e\u003cb\u003eProprietà\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003cp align=\"justify\"\u003e  \u003c\/p\u003e  \u003cdiv class=\"tableResponsive\"\u003e  \u003ctable width=\"100%\" class=\"Table\"\u003e  \u003ctbody\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eSinonimi\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eARIA; GGF; GGF2; HGL; HRG; Neuregulina-1 beta 1; NRG1 beta 1\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eAdesione\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eQ02297\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eGeneID\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e3084\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eFonte\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eDerivato da E.coli NRG1-β1 umano, Ser177-Glu241.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003ePeso molecolare\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eCirca 7.5 unità di misura.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eSequenza AA\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eSHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eEtichetta\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eNessuno\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eAspetto fisico\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003ePolvere liofilizzata (congelata) bianca, filtrata sterile.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003ePurezza\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u0026gt; 97 % mediante analisi SDS-PAGE e HPLC.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eAttività biologica\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eIl DE\u003csub\u003e50\u003c\/sub\u003e come determinato da un test di proliferazione cellulare utilizzando cellule MCF-7 umane prive di siero è inferiore a 0,5 ng\/mL, corrispondente a un'attività specifica di \u0026gt; 2,0 × 10\u003csup\u003e6\u003c\/sup\u003e\u003csup\u003e  \u003c\/sup\u003eUI\/mg. Completamente biologicamente attivo rispetto allo standard. \u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eEndotossina\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u0026lt; 0,1 EU per 1μg di proteina con il metodo LAL.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eFormulazione\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eLiofilizzato da una soluzione filtrata a 0,2 μm in 1 × PBS, pH 7,4, con trealosio al 5%.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003c\/tbody\u003e  \u003c\/table\u003e  \u003c\/div\u003e  \u003c\/div\u003e  \u003cdiv\u003e\u003cbr\u003e\u003c\/div\u003e  \u003cdiv class=\"tableResponsive\"\u003e  \u003ctable width=\"100%\" class=\"Table\"\u003e  \u003ctbody\u003e  \u003ctr\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eRicostituzione\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd valign=\"center\"\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eSi consiglia di centrifugare brevemente questa fiala prima dell'apertura per portare il contenuto sul fondo. Ricostituire in acqua distillata sterile o tampone acquoso contenente 0,1% BSA a una concentrazione di 0,1-1,0 mg\/mL. Le soluzioni madre devono essere suddivise in aliquote di lavoro e conservate a ≤ -20\u003cspan face=\"Times New Roman, Times, serif\" style=\"font-family: 'Times New Roman', Times, serif;\"\u003e℃\u003c\/span\u003eUlteriori diluizioni devono essere effettuate in soluzioni tamponate appropriate.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003c\/tbody\u003e  \u003c\/table\u003e  \u003c\/div\u003e  \u003cp align=\"justify\"\u003e  \u003c\/p\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eS\u003c\/b\u003e\u003cb\u003ehipping\u003c\/b\u003e\u003cb\u003e e S.\u003c\/b\u003e\u003cb\u003estoccaggio\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003cp align=\"justify\"\u003e  \u003c\/p\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eI prodotti vengono spediti con ghiaccio e possono essere conservati a -20\u003cspan face=\"Times New Roman, Times, serif\" style=\"font-family: 'Times New Roman', Times, serif;\"\u003e℃\u003c\/span\u003e per 1 anno.\u003c\/span\u003e\u003c\/p\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e1 mese, da 2 a 8 °C in condizioni sterili dopo la ricostituzione.\u003c\/span\u003e\u003c\/p\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e3 mesi, da -20 a -70 °C in condizioni sterili dopo la ricostituzione.\u003c\/span\u003e\u003c\/p\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003eSi consiglia di suddividere la proteina in quantità più piccole al primo utilizzo ed evitare ripetuti cicli di congelamento-scongelamento.\u003c\/span\u003e\u003c\/p\u003e  \u003cp align=\"justify\"\u003e  \u003c\/p\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cb\u003eAttenzione\u003c\/b\u003e\u003cb\u003eS\u003c\/b\u003e\u003c\/span\u003e\u003c\/p\u003e  \u003cp align=\"justify\"\u003e  \u003c\/p\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cspan face=\"Times New Roman, Times, serif\" style=\"font-family: 'Times New Roman', Times, serif;\"\u003e1.\u003c\/span\u003eEvitare ripetuti cicli di congelamento-scongelamento.\u003c\/span\u003e\u003c\/p\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cspan face=\"Times New Roman, Times, serif\" style=\"font-family: 'Times New Roman', Times, serif;\"\u003e2.\u003c\/span\u003ePer la vostra sicurezza e salute, vi preghiamo di indossare camici da laboratorio e guanti monouso durante il funzionamento.\u003c\/span\u003e\u003c\/p\u003e  \u003cp align=\"justify\"\u003e\u003cspan\u003e\u003cspan face=\"Times New Roman, Times, serif\" style=\"font-family: 'Times New Roman', Times, serif;\"\u003e3.\u003c\/span\u003eSolo per uso di ricerca!\u003c\/span\u003e\u003c\/p\u003e","brand":"Yeasen","offers":[{"title":"10 ug","offer_id":53302321414462,"sku":"92140ES10","price":75.0,"currency_code":"USD","in_stock":true},{"title":"100 ug","offer_id":53302321447230,"sku":"92140ES60","price":390.0,"currency_code":"USD","in_stock":true},{"title":"500 ug","offer_id":53302321479998,"sku":"92140ES76","price":940.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0803\/9419\/1166\/files\/92140_06e8840e-75da-4f92-a9e4-110789677321.png?v=1776042824","url":"https:\/\/www.yeasenbio.com\/it\/products\/92140","provider":"Yeasen - Leading Innovation in Molecular Enzymes and Reagents","version":"1.0","type":"link"}