{"product_id":"90906","title":"Crescita umana ricombinante Regolata G-Gamma\/CXCL3 (GRO-γ\/CXCL3) _ 90906ES","description":"\u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eGRO alfa, GRO beta (MIP-2 alfa) e GRO gamma (MIP-2 beta) umani sono prodotti di tre geni umani distinti e non allelici. GRO beta e GRO gamma condividono rispettivamente il 90% e l'86% di omologia di sequenza aminoacidica con GRO alfa. Tutti e tre i GRO umani sono membri della sottofamiglia alfa (CXC) delle chemiochine e si pensa che siano gli omologhi di KC e MIP-2 murini.\u003c\/span\u003e\u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eI tre cDNA GRO codificano 107 proteine ​​precursori di aminoacidi da cui i 34 residui di aminoacidi N-terminali vengono scissi per generare i GRO maturi. Non ci sono potenziali siti di glicosilazione N-linked nelle sequenze di aminoacidi. L'espressione di GRO è inducibile da siero o PDGF e\/o da una varietà di mediatori infiammatori, come IL-1 e TNF, in monociti, fibroblasti, melanociti e cellule epiteliali. In alcune linee cellulari tumorali, GRO è espresso in modo costitutivo.\u003c\/span\u003e\u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eSimilmente ad altre chemiochine alfa, le tre proteine ​​GRO sono potenti attrattivi e attivatori dei neutrofili. Inoltre, queste chemiochine sono anche attive verso i basofili. Tutte e tre le GRO possono legarsi con elevata affinità al recettore IL-8 di tipo B.\u003c\/span\u003e\u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e  \u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eProdotto \u003c\/span\u003e\u003c\/strong\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eProprietà\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003cdiv class=\"tableResponsive\" data-mce-fragment=\"1\"\u003e  \u003ctable width=\"100%\" cellspacing=\"0\" data-mce-fragment=\"1\"\u003e  \u003ctbody data-mce-fragment=\"1\"\u003e  \u003ctr class=\"firstRow\" data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eSinonimi\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eGRO-gamma, MIP2-beta\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAdesione\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eP19876\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eGeneID\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e2921\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eFonte\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eE.coli derivato dall'uomo \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003eGRO-γ\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e,Ala35-Asn107.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003ePeso molecolare\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eCirca 7,9 kDa\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eSequenza AA\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eASVVTELRCQ CLQTLQGIHL KNIQSVNVRS PGPHCAQTEV IATLKNGKKA CLNPASPMVQ KIIEKILNKG STN\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eEtichetta\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eNessuno\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAspetto fisico\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003ePolvere liofilizzata (congelata) bianca, filtrata sterile.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003ePurezza\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u0026gt; 97% mediante analisi SDS-PAGE e HPLC.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAttività biologica\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eCompletamente biologicamente attivo rispetto allo standard. L'attività biologica determinata da un biotest di chemiotassi utilizzando cellule umane 293 transfettate con CXCR2 è in un intervallo di concentrazione di 10-100 ng\/m\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003eL\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eEndotossina\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e\u0026lt;  1 EU per 1μg di proteina con il metodo LAL.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eFormulazione\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eLiofilizzato da una soluzione concentrata filtrata a 0,2 µm in 20 mM PB, pH 7,4, 50 mM NaCl.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003ctr data-mce-fragment=\"1\"\u003e  \u003ctd width=\"124\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eRicostituzione\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003ctd width=\"526\" valign=\"center\" data-mce-fragment=\"1\"\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eSi consiglia di centrifugare brevemente questa fiala prima dell'apertura per portare il contenuto sul fondo. Ricostituire in acqua distillata sterile o tampone acquoso contenente 0,1% di BSA a una concentrazione di 0,1-1,0 mg\/mL.Le soluzioni stock devono essere suddivise in aliquote di lavoro e conservate a ≤ -20°C. Ulteriori diluizioni devono essere effettuate in soluzioni tamponate appropriate.\u003c\/span\u003e\u003c\/p\u003e  \u003c\/td\u003e  \u003c\/tr\u003e  \u003c\/tbody\u003e  \u003c\/table\u003e  \u003c\/div\u003e  \u003cp data-mce-fragment=\"1\"\u003e  \u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eSpedizione e stoccaggio\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eI prodotti vengono spediti con ghiaccio e possono essere conservati a \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e-\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e20\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e℃ a -80℃\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e per \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e1\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e anno.\u003c\/span\u003e\u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eSi consiglia di suddividere la proteina in quantità più piccole al primo utilizzo\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003e  \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003eed evitare ripetuti congelamenti\u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003escongelare \u003c\/span\u003e\u003cspan data-mce-fragment=\"1\"\u003ecicli.\u003c\/span\u003e\u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e  \u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cstrong data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003eAttenzione\u003c\/span\u003e\u003c\/strong\u003e\u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e1. Evitare ripetuti cicli di congelamento-scongelamento.\u003c\/span\u003e\u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e2. Per la vostra sicurezza e salute, vi preghiamo di indossare camici da laboratorio e guanti monouso durante il funzionamento.\u003c\/span\u003e\u003c\/p\u003e  \u003cp data-mce-fragment=\"1\"\u003e\u003cspan data-mce-fragment=\"1\"\u003e3. Solo per uso di ricerca.\u003c\/span\u003e\u003c\/p\u003e","brand":"Yeasen","offers":[{"title":"100 ug","offer_id":53213668114750,"sku":"90906ES60","price":565.0,"currency_code":"USD","in_stock":true},{"title":"500 ug","offer_id":53213668147518,"sku":"90906ES76","price":1410.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0803\/9419\/1166\/products\/20220513162505336_ae34779f-37e4-4793-819f-f925c62d95a5.jpg?v=1708077079","url":"https:\/\/www.yeasenbio.com\/it\/products\/90906","provider":"Yeasen - Leading Innovation in Molecular Enzymes and Reagents","version":"1.0","type":"link"}