{"product_id":"13005","title":"Ionizable Lipid HNC2440 _ 13005ES","description":"\u003cp class=\"MsoNormal\" align=\"justify\"\u003e\u003cspan\u003eHNC2440 is an ionizable lipid designed for the assembly of lipid nanoparticles (LNPs) for nucleic acid delivery. It complexes with negatively charged RNA and co-assembles with phospholipids, cholesterol, and PEG lipids to form LNPs. Following cellular uptake via endocytosis, the RNA-loaded particles escape from endosomes and release their cargo, after which the liberated mRNA is translated into protein by ribosomes. HNC2440 is characterized by high delivery efficiency and rapid clearance.\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003cspan style=\"font-size: 0.875rem;\"\u003e \u003c\/span\u003e\u003c\/p\u003e\n\u003ch3\u003e\n\u003cb\u003e\u003cspan class=\"15\"\u003eSpecifications\u003c\/span\u003e\u003c\/b\u003e\u003cb\u003e\u003cspan class=\"15\"\u003e\u003c\/span\u003e\u003c\/b\u003e\n\u003c\/h3\u003e\n\u003ctable class=\"MsoTableGrid\" border=\"1\" cellspacing=\"0\"\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\" valign=\"center\"\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan\u003eProduct Name\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"615\" valign=\"top\"\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan\u003eIonizable Lipid HNC2440\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\" valign=\"top\"\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan\u003eMolecular Formula\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"615\" valign=\"top\"\u003e\n\u003cp class=\"16\" align=\"justify\"\u003e\u003cspan\u003eC\u003c\/span\u003e\u003csub\u003e\u003cspan\u003e46\u003c\/span\u003e\u003c\/sub\u003e\u003cspan\u003eH\u003c\/span\u003e\u003csub\u003e\u003cspan\u003e89\u003c\/span\u003e\u003c\/sub\u003e\u003cspan\u003eNO\u003c\/span\u003e\u003csub\u003e\u003cspan\u003e4\u003c\/span\u003e\u003c\/sub\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\" valign=\"top\"\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan\u003eMolecular Weight\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"615\" valign=\"top\"\u003e\n\u003cp class=\"16\" align=\"justify\"\u003e\u003cspan\u003e720.22\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\" valign=\"top\"\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan\u003eCAS No.\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"615\" valign=\"top\"\u003e\n\u003cp class=\"16\" align=\"justify\"\u003e\u003cspan\u003eNA\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd width=\"237\" valign=\"top\"\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan\u003ePurity\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003ctd width=\"615\" valign=\"top\"\u003e\n\u003cp class=\"16\" align=\"justify\"\u003e\u003cspan\u003eHPLC ≥97%\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003ch3\u003e\n\u003cb\u003e\u003cspan class=\"15\"\u003e\u003cspan style=\"font-family: Inter;\"\u003eApplication\u003c\/span\u003e\u003c\/span\u003e\u003c\/b\u003e\u003cb\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/b\u003e\n\u003c\/h3\u003e\n\u003cp class=\"MsoNormal\" align=\"justify\"\u003e\u003cspan\u003eFor the in vitro and in vivo studies, LNPs were formulated at a molar ratio of HNC2440 : cholesterol : DSPC : DMG-PEG2k = 48.5 : 38.9 : 11.1 : 1.5 with an N\/P ratio of 4.84, and encapsulated using a microfluidic mixing process.\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003ch3 class=\"MsoNormal\" align=\"justify\"\u003e\n\u003cb\u003e\u003cspan class=\"15\"\u003eFigures\u003c\/span\u003e\u003c\/b\u003e\u003cspan\u003e\u003c\/span\u003e\n\u003c\/h3\u003e\n\u003cp align=\"justify\"\u003e\u003cb\u003e\u003cspan class=\"15\"\u003e\u003cspan style=\"font-family: Inter;\"\u003e1. Delivery Efficiency\u003c\/span\u003e\u003c\/span\u003e\u003c\/b\u003e\u003cb\u003e\u003cspan class=\"15\"\u003e\u003c\/span\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\" align=\"justify\"\u003e\u003cspan\u003eThe delivery efficiency of Fluc mRNA LNP (left) and Gluc mRNA LNP (right) prepared with HNC2440 in mice is comparable to that of LNPs prepared with a clinically used ionizable lipid.\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0803\/9419\/1166\/files\/1_15f031d7-1185-4bc7-b9f4-f14b10e97655.png?v=1794205770\" alt=\"Figure 1. Delivery efficiency of Fluc mRNA LNP and Gluc mRNA LNP prepared with HNC2440 in mice\" style=\"margin-bottom: 16px; float: none;\"\u003e\u003c\/div\u003e\n\u003cp class=\"MsoNormal\" align=\"center\"\u003e\u003cb\u003e\u003cspan\u003eFigure 1. Delivery efficiency of Fluc mRNA LNP and Gluc mRNA LNP prepared with HNC2440 in mice\u003c\/span\u003e\u003c\/b\u003e\u003cb\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp align=\"justify\"\u003e\u003c!-- [if !supportLists]--\u003e\u003cstrong\u003e\u003cspan style=\"mso-list: Ignore;\"\u003e2. \u003c\/span\u003e\u003c\/strong\u003e\u003c!--[endif]--\u003e\u003cb\u003e\u003cspan class=\"15\"\u003e\u003cspan style=\"font-family: Inter;\"\u003eClearance in Liver and Spleen\u003c\/span\u003e\u003c\/span\u003e\u003c\/b\u003e\u003cb\u003e\u003cspan class=\"15\"\u003e\u003c\/span\u003e\u003c\/b\u003e\u003c\/p\u003e\n\u003cp class=\"MsoNormal\"\u003e\u003cspan\u003eFollowing tail-vein injection of 0.1 mg\/kg Fluc mRNA LNP, residual ionizable lipid levels in the liver and spleen were measured at multiple time points. HNC2440 was cleared from both organs significantly faster than the clinically used ionizable lipid.\u003c\/span\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/p\u003e\n\u003cdiv style=\"text-align: center;\"\u003e\n\u003cimg src=\"https:\/\/cdn.shopify.com\/s\/files\/1\/0803\/9419\/1166\/files\/2_60cf6f41-4157-4c72-b08a-e0eba65ac6a9.png?v=1794205770\" alt=\"Figure 2. Residual ionizable lipid in the liver and spleen after intravenous administration of Fluc mRNA LNP\" style=\"margin-bottom: 16px; float: none;\"\u003e\u003cspan\u003e \u003c\/span\u003e\u003cb\u003e\u003cspan\u003eFigure 2. Residual ionizable lipid in the liver and spleen after intravenous administration of Fluc mRNA LNP\u003c\/span\u003e\u003c\/b\u003e\u003cb\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/b\u003e\u003cb\u003e\u003cspan\u003e\u003c\/span\u003e\u003c\/b\u003e\n\u003c\/div\u003e","brand":"Yeasen","offers":[{"title":"1 g","offer_id":54885686182206,"sku":"C130050S","price":1305.0,"currency_code":"USD","in_stock":true},{"title":"5 g","offer_id":54885686214974,"sku":"C130050M","price":5505.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0803\/9419\/1166\/files\/aaa.jpg?v=1790646283","url":"https:\/\/www.yeasenbio.com\/ar\/products\/13005","provider":"Yeasen - Leading Innovation in Molecular Enzymes and Reagents","version":"1.0","type":"link"}